The vagus nerve and the inflammatory reflex-linking immunity and metabolism

被引：648
作者：
Pavlov, Valentin A. [1 ]
Tracey, Kevin J. [1 ]
机构：
[1] Feinstein Inst Med Res, Ctr Biomed Sci, Manhasset, NY 11030 USA
来源：
NATURE REVIEWS ENDOCRINOLOGY | 2012年 / 8卷 / 12期
关键词：
CHOLINERGIC ANTIINFLAMMATORY PATHWAY; DIET-INDUCED OBESITY; TERM VAGAL-STIMULATION; HEART-RATE-VARIABILITY; ADIPOSE-TISSUE; FOOD-INTAKE; INSULIN-RESISTANCE; GUT MICROBIOTA; ACETYLCHOLINE-RECEPTORS; STERILE INFLAMMATION;
D O I：
10.1038/nrendo.2012.189
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The vagus nerve has an important role in regulation of metabolic homeostasis, and efferent vagus nerve-mediated cholinergic signalling controls immune function and proinflammatory responses via the inflammatory reflex. Dysregulation of metabolism and immune function in obesity are associated with chronic inflammation, a critical step in the pathogenesis of insulin resistance and type 2 diabetes mellitus. Cholinergic mechanisms within the inflammatory reflex have, in the past 2 years, been implicated in attenuating obesity-related inflammation and metabolic complications. This knowledge has led to the exploration of novel therapeutic approaches in the treatment of obesity-related disorders.
引用
收藏
页码：743 / 754
页数：12
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