The development of a QALY measure for epilepsy: NEWQOL-6D

被引：53

作者：

Mulhern, Brendan ^{[1
]}

Rowen, Donna ^{[1
]}

Jacoby, Ann ^{[2
]}

Marson, Tony ^{[3
]}

Snape, Dee ^{[2
]}

Hughes, Dyfrig ^{[4
]}

Latimer, Nick ^{[1
]}

Baker, Gus A. ^{[3
]}

Brazier, John E. ^{[1
]}

机构：

[1] Univ Sheffield, Sch Hlth & Related Res, Sheffield SI 4DA, S Yorkshire, England

[2] Univ Liverpool, Sch Populat Community & Behav Sci, Liverpool L69 3BX, Merseyside, England

[3] Univ Liverpool, Div Neurol Sci, Liverpool L69 3BX, Merseyside, England

[4] Bangor Univ, Ctr Hlth Econ & Med Evaluat, Bangor, Gwynedd, Wales

来源：

EPILEPSY & BEHAVIOR | 2012年 / 24卷 / 01期

关键词：

Epilepsy; Cost-utility analysis; Resource allocation; QALY; Preference-based measure; Rasch analysis; Utility; Health state valuation; Factor analysis; PREFERENCE-BASED MEASURE; QUALITY-OF-LIFE; HEALTH STATE CLASSIFICATION; HOSPITAL ANXIETY; DEPRESSION SCALE; VALIDITY; EUROQOL; EVENTS; PEOPLE; INDEX;

D O I：

10.1016/j.yebeh.2012.02.025

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Cost-utility analysis is used to inform the allocation of healthcare resources, using the quality-adjusted life year (QALY) as the outcome measure. We report the development of an epilepsy-specific QALY measure (NEWQOL-6D) derived from the NEWQOL measure of health-related quality of life. Firstly, psychometric and Rasch analyses established the dimension structure of NEWQOL and generated a reduced health state classification system including one item per dimension. Secondly, health states generated by the classification system were valued using Time Trade Off, and the results were modeled to generate a utility score for every health state. A classification system with 6 dimensions (worry about attacks; depression; memory; concentration; stigma; control) was produced, and generalized least squares regression was used to generate utility scores for every health state. This study is the first attempt to derive an epilepsy-specific QALY measure, and the utility values can be used in the economic evaluation of emerging technologies for epilepsy. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：36 / 43

页数：8

共 31 条

[1] Patient-based assessments of quality of life in newly diagnosed epilepsy patients: Validation of the NEWQOL [J].