DNA-Nanostructure-Gold-Nanorod Hybrids for Enhanced In Vivo Optoacoustic Imaging and Photothermal Therapy

被引：183
作者：
Du, Yang [1 ]
Jiang, Qiao [2 ,3 ]
Beziere, Nicolas [4 ,5 ]
Song, Linlin [2 ]
Zhang, Qian [1 ]
Peng, Dong [1 ]
Chi, Chongwei [1 ]
Yang, Xin [1 ]
Guo, Hongbo [2 ]
Diot, Gael [4 ,5 ]
Ntziachristos, Vasilis [4 ,5 ]
Ding, Baoquan [2 ]
Tian, Jie [1 ]
机构：
[1] Chinese Acad Sci, Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Inst Automat, Beijing 100190, Peoples R China
[2] Natl Ctr Nanosci & Technol, CAS Key Lab Nanosyst & Hierarch Fabricat, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China
[3] Chinese Acad Sci, Inst Chem, CAS Key Lab Colloid Interface & Chem Thermodynam, Beijing 100190, Peoples R China
[4] Helmholtz Zentrum Munchen, Inst Biol & Med Imaging, D-85764 Neuherberg, Germany
[5] Tech Univ Munich, D-85764 Neuherberg, Germany
来源：
ADVANCED MATERIALS | 2016年 / 28卷 / 45期
基金：
北京市自然科学基金; 中国国家自然科学基金;
关键词：
OPTICAL CONTRAST AGENT; PHOTOACOUSTIC TOMOGRAPHY; LIVING MICE; CANCER; NANOPARTICLES; TISSUE; NANOMATERIALS; DELIVERY; ORIGAMI; FLUORESCENT;
D O I：
10.1002/adma.201601710
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A functional cancer theranostic nanoplatform is developed, specifically tailored toward the optoacoustic modality by combining gold nanorods with DNA nanostructures (D-AuNR). DNA origami is used as an efficient delivery vehicle owing to its prominent tumor-targeting property. The D-AuNR hybrids display an enhanced tumor diagnostic sensitivity by improved optoacoustic imaging and excellent photothermal therapeutic properties in vivo.
引用
收藏
页码：10000 / 10007
页数：8
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