Low plasma cefepime levels in critically ill septic patients: Pharmacokinetic modeling indicates improved troughs with revised dosing

被引：92
作者：
Lipman, J
Wallis, SC
Rickard, C
机构：
[1] Royal Brisbane Hosp, Intens Care Facil, Brisbane, Qld 4029, Australia
[2] Univ Queensland, Div Anaesthesiol & Intens Care, St Lucia, Qld 4067, Australia
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 10期
关键词：
D O I：
10.1128/AAC.43.10.2559
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The pharmacokinetics of a 2-g bolus of cefepime were measured in critically ill patients with normal renal function. Variable and low trough plasma drug concentrations were found, and 8 of 10 patients had levels below the MIC at which 50% of the isolates are inhibited for Pseudomonas aeruginosa. Computer simulations predicted that continuous infusion and shorter dosing intervals would increase trough levels.
引用
收藏
页码：2559 / 2561
页数：3
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