Bioelectrochemistry for miRNA detection

被引：19

作者：

Ciui, Bianca ^{[1
,3
]}

Jambrec, Daliborka ^{[2
]}

Sandulescu, Robert ^{[1
]}

Cristea, Cecilia ^{[1
]}

机构：

[1] Iuliu Hatieganu Univ Med & Pharm, Dept Analyt Chem, 4 Louis Pasteur St, Cluj Napoca 400349, Romania

[2] Ruhr Univ Bochum, AnalyticalChem, CES, Univ Str 150, D-44780 Bochum, Germany

[3] Univ Calif San Diego, Dept Nanoengn, La Jolla, CA 92093 USA

来源：

CURRENT OPINION IN ELECTROCHEMISTRY | 2017年 / 5卷 / 01期

关键词：

ROLLING CIRCLE AMPLIFICATION; ELECTROCHEMICAL DETECTION; ULTRASENSITIVE DETECTION; CIRCULATING MICRORNA; SENSITIVE DETECTION; BIOMARKERS; BIOSENSORS; CANCER; PERFORMANCE; DIAGNOSIS;

D O I：

10.1016/j.coelec.2017.09.014

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Anomalous expression of miRNAs has been linked with cell cycles such as cell proliferation, stress response, differentiation, cell apoptosis and inflammation, which present a manifestation of multitude types of disorders and malignancies. For this reason, miRNAs became a class of biomarkers that is in the research focus in recent years. Their detection in an early stage of diseases represents a difficult challenge for analytical chemists who need to design not only specific but also highly sensitive tools for their detection. The progress achieved in the bio-electrochemical detection of miRNAs in the last 2 years is highlighted and commented, focusing on the applicability of developed strategies for point-of-care sensing.

引用

页码：183 / 192

页数：10

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