Current developments in the discovery and design of new drug candidates from plant natural product leads

被引：150
作者：
Lee, KH [1 ]
机构：
[1] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 02期
关键词：
D O I：
10.1021/np030373o
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
This review article will emphasize recent research in the Natural Products Laboratory, School of Pharmacy, University of North Carolina at Chapel Hill, on various classes of plant-derived compounds that possess potent antitumor or anti-HIV activity. These compounds were obtained by bioactivity- and mechanism of action-directed isolation and characterization coupled with rational drug design-based modification and analogue synthesis. Structural modification, SAR, and mechanism of action studies are discussed.
引用
收藏
页码：273 / 283
页数：11
相关论文
共 97 条
  • [1] Aggarwal BB, 2003, ANTICANCER RES, V23, P363
  • [2] STRUCTURE-ACTIVITY-RELATIONSHIPS OF DIMERIC CATHARANTHUS ALKALOIDS .1. DEACETYLVINBLASTINE AMIDE (VINDESINE) SULFATE
    BARNETT, CJ
    CULLINAN, GJ
    GERZON, K
    HOYING, RC
    JONES, WE
    NEWLON, WM
    POORE, GA
    ROBISON, RL
    SWEENEY, MJ
    TODD, GC
    DYKE, RW
    NELSON, RL
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1978, 21 (01) : 88 - 96
  • [3] INDUCTION OF REVERSIBLE PROTEIN-LINKED DNA BREAKS IN HUMAN OSTEOGENIC-SARCOMA CELLS BY NOVEL CYTOCIDAL COLCHICINE DERIVATIVES WHICH INHIBIT DNA TOPOISOMERASE-II INVITRO - ABSENCE OF CROSS-RESISTANCE IN A COLCHICINE-RESISTANT SUB-CLONE
    BASTOW, KF
    TATEMATSU, H
    BORI, ID
    FUKUSHIMA, Y
    SUN, L
    GOZ, B
    LEE, KH
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1993, 3 (06) : 1045 - 1050
  • [4] Antitumor agents .173. Synthesis and evaluation of camptothecin-4 beta-amino-4'-O-demethyl epipodophyllotoxin conjugates as inhibitors of mammalian DNA topoisomerases and as cytotoxic agents
    Bastow, KF
    Wang, HK
    Cheng, YC
    Lee, KH
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 1997, 5 (08) : 1481 - 1488
  • [5] BROSSI A, 1984, ALKALOIDS, pCH23
  • [6] Unique biochemical, cytotoxic, and antitumor activity of camptothecin and 4β-amino-4'-O-demethylepipodophyllotoxin conjugates
    Chang, JY
    Guo, X
    Chen, HX
    Jiang, ZL
    Fu, Q
    Wang, HK
    Bastow, KF
    Zhu, XK
    Guan, J
    Lee, KH
    Cheng, YC
    [J]. BIOCHEMICAL PHARMACOLOGY, 2000, 59 (05) : 497 - 508
  • [7] CHANG JY, 1991, CANCER RES, V51, P1755
  • [8] Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior
    Chen, DF
    Zhang, SX
    Chen, K
    Zhou, BN
    Wang, P
    Cosentino, LM
    Lee, KH
    [J]. JOURNAL OF NATURAL PRODUCTS, 1996, 59 (11): : 1066 - 1068
  • [9] Antitumor agents .178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization
    Chen, K
    Kuo, SC
    Hsieh, MC
    Mauger, A
    Lin, CM
    Hamel, E
    Lee, KH
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (19) : 3049 - 3056
  • [10] ANTI-AIDS AGENTS .4. TRIPTERIFORDIN, A NOVEL ANTI-HIV PRINCIPLE FROM TRIPTERYGIUM-WILFORDII - ISOLATION AND STRUCTURAL ELUCIDATION
    CHEN, K
    SHI, Q
    FUJIOKA, T
    ZHANG, DC
    HU, CQ
    JIN, JQ
    KILKUSKIE, RE
    LEE, KH
    [J]. JOURNAL OF NATURAL PRODUCTS, 1992, 55 (01): : 88 - 92
12345678910