Template-directed excimer formation via specific non-covalent interactions between pyrene guanidinium derivatives and nucleic acids

被引：5

作者：

Amirbekyan, Karen ^{[1
,2
]}

Mansot, Justine ^{[1
]}

Ohara, Keiichiro ^{[1
]}

Markarian, Shiraz A. ^{[2
]}

Vasseur, Jean-Jacques ^{[1
]}

Smietana, Michael ^{[1
]}

机构：

[1] Univ Montpellier, CNRS, ENSCM, Inst Biomol Max Mousseron,UMR 5247, Pl Eugene Bataillon, F-34095 Montpellier, France

[2] Yerevan State Univ, Dept Phys Chem, 1 Alex Manoogian, Yerevan 0025, Armenia

来源：

TETRAHEDRON LETTERS | 2018年 / 59卷 / 03期

关键词：

Excimer fluorescence; Pyrene; Nucleic acids; G-quadruplex; G-QUADRUPLEX DNA; RATIOMETRIC FLUORESCENCE; CIRCULAR-DICHROISM; BINDING; PROBE; COMPLEXES; STRATEGY; CATIONS; ANIONS; MALDI;

D O I：

10.1016/j.tetlet.2017.12.046

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Structurally distinct guanidinium derivatives were evaluated for their ability to interact non-covalently with various nucleic acid sequences. Among the evaluated derivatives, 4-[(pyrene-1-ylmethyl)amino] butyl] guanidinium (pbg) was found to demonstrate strong excimer emission upon nucleic acid addition and high levels of discrimination between ds- and ss-DNA. The intensity of excimer emission proved to be dependent on the length of the linker probe as well as the oligonucleotide length and sequence. In particular, G-quadruplex prone structures were found to induce the highest excimer emissions among all nucleic acids tested. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：295 / 298

页数：4

共 31 条

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