The toll-like receptor 3 pathway in homeostasis, responses to injury and wound repair

被引：34
|
作者：
Ramnath, Divya [1 ,2 ,3 ]
Powell, Elizabeth E. [4 ,5 ]
Scholz, Glen M. [6 ,7 ,8 ]
Sweet, Matthew J. [1 ,2 ,3 ]
机构：
[1] Univ Queensland, IMB, Brisbane, Qld 4072, Australia
[2] Univ Queensland, IMB Ctr Inflammat & Dis Res, Brisbane, Qld 4072, Australia
[3] Univ Queensland, Australian Infect Dis Res Ctr, Brisbane, Qld 4072, Australia
[4] Univ Queensland, Translat Res Inst, Sch Med, Ctr Liver Dis Res, Brisbane, Qld 4102, Australia
[5] Princess Alexandra Hosp, Dept Gastroenterol & Hepatol, Brisbane, Qld 4102, Australia
[6] Univ Melbourne, Melbourne Dent Sch, Parkville, Vic 3010, Australia
[7] Univ Melbourne, Oral Hlth Cooperat Res Ctr, Parkville, Vic 3010, Australia
[8] Univ Melbourne, Mol Sci & Biotechnol Inst Bio21, Parkville, Vic 3010, Australia
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2017年 / 61卷
基金：
英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;
关键词：
Toll-like receptor 3; Wound repair; Homeostasis; Ischemia reperfusion injury; Poly(IC); UV-damage; NF-KAPPA-B; DOUBLE-STRANDED-RNA; POLYINOSINIC-POLYCYTIDYLIC ACID; INTERFERON REGULATORY FACTOR-3; HERPES-SIMPLEX ENCEPHALITIS; NORMAL HUMAN KERATINOCYTES; INNATE IMMUNE-RESPONSE; TLR3; DEFICIENCY; HEPATITIS-B; IN-VITRO;
D O I：
10.1016/j.semcdb.2016.08.014
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In addition to their established roles in host defence, Toll-like Receptors (TLRs) have emerging roles in control of homeostasis, injury and wound repair. The dsRNA-sensing receptor, TLR3, has been particularly implicated in such processes in several different tissues including the skin, intestine and liver, as well as in the control of reparative mechanisms in the brain, heart and kidneys, following ischemia reperfusion injury. In this review, we provide an overview of TLR3 signalling and functions in inflammation, tissue damage and repair processes, as well as therapeutic opportunities that may arise in the future from knowledge of such pathways. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：22 / 30
页数：9
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