The potential of induced pluripotent stem cells for discriminating neurodevelopmental disorders

被引：3
|
作者：
Stock, Ricarda [1 ]
Jeckel, Pauline [1 ]
Kraushaar, Udo [1 ]
Wuest, Richard [2 ]
Fallgatter, Andreas [2 ]
Volkmer, Hansjuergen [1 ]
机构：
[1] Univ Tubingen, NMI Nat & Med Sci Inst, Dept Mol Biol, Reutlingen, Germany
[2] Univ Tubingen, Dept Psychiat, Tubingen, Germany
来源：
STEM CELLS TRANSLATIONAL MEDICINE | 2021年 / 10卷 / 01期
关键词：
autism; calcium imaging; electrophysiology; iPSC; schizophrenia; transcriptome; AUTISM SPECTRUM DISORDER; DELETION SYNDROME; GENE-EXPRESSION; SCHIZOPHRENIA; NEURONS; MODEL; DIFFERENTIATION; DYSREGULATION; NEUROGENESIS; CONNECTIVITY;
D O I：
10.1002/sctm.20-0206
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Studying human disease-specific processes and mechanisms in vitro is limited by a lack of valid human test systems. Induced pluripotent stem cells (iPSCs) evolve as an important and promising tool to better understand the molecular pathology of neurodevelopmental disorders. Patient-derived iPSCs enable analysis of unique disease mechanisms and may also serve for preclinical drug development. Here, we review the current knowledge on iPSC models for schizophrenia and autism spectrum disorders with emphasis on the discrimination between them. It appears that transcriptomic analyses and functional read-outs are the most promising approaches to uncover specific disease mechanisms in vitro.
引用
收藏
页码：50 / 56
页数：7
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