Free radical scavengers: An overview on heterocyclic advances and medicinal prospects

被引：68

作者：

Haider, Kashif ^{[1
]}

Haider, Md Rafi ^{[1
]}

Neha, Kumari ^{[1
]}

Yar, M. Shahar ^{[1
]}

机构：

[1] Jamia Hamdard, Dept Pharmaceut Chem, Sch Pharmaceut Educ & Res, New Delhi 110062, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2020年 / 204卷

关键词：

Synthetic radical scavengers; Heterocycles; SAR Study; Antioxidants; LOW-DENSITY-LIPOPROTEIN; IN-VITRO EVALUATION; ANTIOXIDANT ACTIVITY; OXIDATIVE STRESS; ROSMARINIC ACID; CAFFEIC ACID; DERIVATIVES SYNTHESIS; NEOCHLOROGENIC ACID; INDOLE-DERIVATIVES; CHLOROGENIC ACIDS;

D O I：

10.1016/j.ejmech.2020.112607

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the present scenario, there has been a lot of consideration toward the field of free radical chemistry. Free radicals responsive oxygen species are produced by different endogenous frameworks, exposure to various physicochemical conditions, radiation, toxins, metabolized drug by-product, and pathological states. On the off chance that free radical overpowers the body's capacity, it generates a condition known as oxidative stress, which can alter physiological conditions of the body and results in several diseases. For appropriate physiological function, it is necessary to have a proper balance between free radicals and antioxidants. Antioxidants chemically inhibit the oxidation process; they are also known as free radical scavengers. For tackling the problem of oxidative stress application of an external source of antioxidant is helpful. A lot of antioxidants of natural, semi-synthetic and synthetic origin are in use, with time search of more effective, nontoxic, safe antioxidant is intensified. The present review, discuss different synthetic derivatives bearing various heterocyclic scaffolds as radical scavengers. (C) 2020 Elsevier Masson SAS. All rights reserved.

引用

页数：16

共 122 条

[21] New 4-N-phenylaminoquinoline derivatives as antioxidant, metal chelating and cholinesterase inhibitors for Alzheimer's disease [J].

Cai, Rong ;

Wang, Li-Ning ;

Fan, Jing-Jing ;

Geng, Shang-Qi ;

Liu, Yu-Ming .

BIOORGANIC CHEMISTRY, 2019, 93

[22] 1-(3-cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1,3-dihydroimidazol-2-one:: A selective high-affinity antagonist for the human dopamine D4 receptor with excellent selectivity over ion channels [J].

Carling, RW ;

Moore, KW ;

Moyes, CR ;

Jones, EA ;

Bonner, K ;

Emms, F ;

Marwood, R ;

Patel, S ;

Fletcher, AE ;

Beer, M ;

Sohal, B ;

Pike, A ;

Leeson, PD .

JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (14) :2706-2715

[23] Design and Discovery of Some Novel Chalcones as Antioxidant and Anti-Inflammatory Agents via Attenuating NF-κB [J].

Chu, Jun ;

Guo, Chun-Liang .

ARCHIV DER PHARMAZIE, 2016, 349 (01) :63-70

[24] Electrochemical Oxidative Aromatizationof 9-Substituted 9,10-Dihydroacridines: Cleavage of C-H vs C-X Bond [J].

Chupakhin, Oleg N. ;

Shchepochkin, Alexander V. ;

Charushin, Valery N. ;

Maiorova, Anna V. ;

Kulikova, Tatyana V. ;

Shunyaev, Konstantin Yu. ;

Enyashin, Andrey N. ;

Slepukhin, Pavel A. ;

Suvorova, Anna I. .

CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2019, 55 (10) :956-963

[25] In vitro antioxidant profile of phenolic acid derivatives [J].

Cos, P ;

Rajan, P ;

Vedernikova, I ;

Calomme, M ;

Pieters, L ;

Vlietinck, AJ ;

Augustyns, K ;

Haemers, A ;

Vanden Berghe, D .

FREE RADICAL RESEARCH, 2002, 36 (06) :711-716

[26] Uric acid enhances longevity and endurance and protects the brain against ischemia [J].

Cutler, Roy G. ;

Camandola, Simonetta ;

Feldman, Neil H. ;

Yoon, Jeong Seon ;

Haran, James B. ;

Arguelles, Sandro ;

Mattson, Mark P. .

NEUROBIOLOGY OF AGING, 2019, 75 :159-168

[27] Indole derivatives as multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity of indole hydrazones [J].

Demurtas, Monica ;

Baldisserotto, Anna ;

Lampronti, Ilaria ;

Moi, Davide ;

Balboni, Gianfranco ;

Pacifico, Salvatore ;

Vertuani, Silvia ;

Manfredini, Stefano ;

Onnis, Valentina .

BIOORGANIC CHEMISTRY, 2019, 85 :568-576

[28] Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy [J].

Dgachi, Youssef ;

Sokolov, Olga ;

Luzet, Vincent ;

Godyn, Justyna ;

Panek, Dawid ;

Bonet, Alexandre ;

Martin, Helene ;

Iriepa, Isabel ;

Moraleda, Ignacio ;

Garcia-Iriepa, Cristina ;

Janockova, Jana ;

Richert, Lysiane ;

Soukup, Ondrej ;

Malawska, Barbara ;

Chabchoub, Fakher ;

Marco-Contelles, Jose ;

Ismaili, Lhassane .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 126 :576-589

[29] Antibacterial and Antioxidant Activities of Ursolic Acid and Derivatives [J].

do Nascimento, Patricia G. G. ;

Lemos, Telma L. G. ;

Bizerra, Ayla M. C. ;

Arriaga, Angela M. C. ;

Ferreira, Daniele A. ;

Santiago, Gilvandete M. P. ;

Braz Filho, Raimundo ;

Costa, Jose Galberto M. .

MOLECULES, 2014, 19 (01) :1317-1327

[30] Organoselenium compounds from purines: Synthesis of 6-arylselanylpurines with antioxidant and anticholinesterase activities and memory improvement effect [J].

Duarte, Luis Fernando B. ;

Oliveira, Renata L. ;

Rodrigues, Karline C. ;

Voss, Guilherme T. ;

Godoi, Benhur ;

Schumacher, Ricardo F. ;

Perin, Gelson ;

Wilhelm, Ethel A. ;

Luchese, Cristiane ;

Alves, Diego .

BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 25 (24) :6718-6723

← 1 2 3 4 5 6 7 8 9 10 →