Chemical Composition and Antiproliferative Activity of Supercritical Extract of Citrus grandis (L.) Osbeck Fruits from Korea

被引：10

作者：

Gyawali, Rajendra ^{[1
,2
,3
]}

Jeon, Deok Hyeon ^{[1
]}

Moon, JeongYong ^{[1
]}

Kim, Hyoenji ^{[1
]}

Song, Yeon Woo ^{[1
]}

Hyun, Ho Bong ^{[1
]}

Jeong, Dongkee ^{[1
]}

Cho, Somi Kim ^{[1
,2
]}

机构：

[1] Jeju Natl Univ, Coll Appl Life Sci, Fac Biotechnol, Cheju 690756, South Korea

[2] Jeju Natl Univ, Subtrop Hort Res Inst, Cheju 690756, South Korea

[3] Kathmandu Univ, Dept Pharm, Dhulikhel, Kavre, Nepal

来源：

JOURNAL OF ESSENTIAL OIL BEARING PLANTS | 2012年 / 15卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

Citrus grandis; supercritical CO2 extract; GC-MS; phytochemicals; cancer cells; antiproliferative activity; ESSENTIAL OILS; VOLATILE CONSTITUENTS; CANCER CELLS; BY-PRODUCTS; APOPTOSIS; INDUCTION; ANTIOXIDANT; POMELO; INHIBITION; FLAVONOIDS;

D O I：

10.1080/0972060X.2012.10662594

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Constituents of supercritical CO2 extracts of peel and flesh from pummelo fruits (Citrus grandis Osbeck) were analyzed by gas chromatography-mass spectrometry (GC-MS). In total, 69 constituents were identified while 42 were common in both samples. The identified major constituents are 7-Methoxy-8-(2-oxo-3-methylbutyl) coumarin (11.4 %), (6E,8E,10E)-2,6,11,15-tetramethyl-2,6,8,10,14-hexadecapentaene (5.9 %) and gamma-sitosterol (5.1 %) in peel and hexadecanoic acid (10.0 %), (E,E)-2,4-decadienal (6.3 %) and pentacosane (7.0 %) in flesh extracts. Antiproliferative activity, determined by cell viability assay and cellular morphology observation, revealed that 400 mu g/ml concentration of peel extract possesses significant efficacy and potency for inhibition of human cervical carcinoma HeLa and gastric adenocarcinoma AGS cells.

引用

页码：915 / 925

页数：11

共 44 条

[1] Adams RP., 1989, Identification of essential oils by ion trap mass spectroscopy
[2] Physico-chemical characteristics of citrus seeds and seed oils from Pakistan
Anwar, Farooq
Naseer, Rehana
Bhanger, M. I.
Ashraf, Samia
Talpur, Farah Naz
Aladeduny, Felix Adekunle
[J]. JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 2008, 85 (04) : 321 - 330
[3] Extraction of essential oils from lime (Citrus latifolia Tanaka) by hydrodistillation and supercritical carbon dioxide
Atti-Santos, AC
Rossato, M
Serafini, LA
Cassel, E
Moyna, P
[J]. BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY, 2005, 48 (01) : 155 - 160
[4] Biological effects of essential oils - A review
Bakkali, F.
Averbeck, S.
Averbeck, D.
Waomar, M.
[J]. FOOD AND CHEMICAL TOXICOLOGY, 2008, 46 (02) : 446 - 475
[5] CARMICHAEL J, 1987, CANCER RES, V47, P936
[6] Flavonoids (apigenin, tangeretin) counteract tumor promoter-induced inhibition of intercellular communication of rat liver epithelial cells
Chaumontet, C
Droumaguet, C
Bex, V
Heberden, C
GaillardSanchez, I
Martel, P
[J]. CANCER LETTERS, 1997, 114 (1-2) : 207 - 210
[7] Classification and prediction of free-radical scavenging activities of dangyuja (Citrus grandis Osbeck) fruit extracts using 1H NMR spectroscopy and multivariate statistical analysis
Cho, Somi K.
Yang, Seung-Ok
Kim, So-Hyun
Kim, Hana
Ko, Jeong Soon
Riu, Key Zung
Lee, Hyo-Yeon
Choi, Hyung-Kyoon
[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2009, 49 (02) : 567 - 571
[8] HUMAN METABOLISM OF THE EXPERIMENTAL CANCER THERAPEUTIC AGENT D-LIMONENE
CROWELL, PL
ELSON, CE
BAILEY, HH
ELEGBEDE, A
HAAG, JD
GOULD, MN
[J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1994, 35 (01) : 31 - 37
[9] Cluster and principal component analysis for Kovats retention indices on apolar and polar stationary phases in gas chromatography
Dallos, A.
Ngo, H. S.
Kresz, R.
Heberger, K.
[J]. JOURNAL OF CHROMATOGRAPHY A, 2008, 1177 (01) : 175 - 182
[10] Limonoids as cancer chemopreventive agents
Ejaz, S
Ejaz, A
Matsuda, K
Lim, CW
[J]. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2006, 86 (03) : 339 - 345

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