Automated Glycan Assembly: A Perspective

被引：152

作者：

Guberman, Monica ^{[1
,2
]}

Seeberger, Peter H. ^{[1
]}

机构：

[1] Max Planck Inst Colloids & Interfaces, Dept Biomol Syst, Muhlenberg 1, D-14476 Potsdam, Germany

[2] Free Univ Berlin, Dept Chem & Biochem, Arnimalle 22, D-14195 Berlin, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2019年 / 141卷 / 14期

关键词：

SOLID-PHASE SYNTHESIS; OLIGOSACCHARIDE SYNTHESIS; PEPTIDE-SYNTHESIS; ARABINOGALACTAN; GLYCOSYLATION; ACCESS; CLEAVAGE; LINKER; ARRAYS; TOOLS;

D O I：

10.1021/jacs.9b00638

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The intrinsic complexity of carbohydrate structures has hampered access to pure glycans and hence impeded progress in the glycosciences. Automated Glycan Assembly (AGA) has facilitated the procurement of synthetic glycans, to be used in diagnostics, vaccine development, enzyme characterization and structure function relationship studies. A general approach for obtaining complex glycans from mammalian, bacterial, fungal and plant classes provides molecular tools for glycobiology research. Recent advances in AGA technology pave the way for the production of novel carbohydrate materials. This perspective describes the state-of-the art of AGA and aspects of the technology where additional improvements are needed.

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收藏

页码：5581 / 5592

页数：12

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