Solid-phase synthesis of CD40L mimetics

被引：10

作者：

Bianco, A ^{[1
]}

Fournel, S ^{[1
]}

Wieckowski, S ^{[1
]}

Hoebeke, J ^{[1
]}

Guichard, G ^{[1
]}

机构：

[1] CNRS, Inst Biol Mol & Cellulaire, UPR 9021, F-67084 Strasbourg, France

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2006年 / 4卷 / 08期

关键词：

D O I：

10.1039/b601528j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The C-3-symmetric molecule 1 has been previously shown to mimic CD40 ligand (CD40L) homotrimers and to display effector functions. This molecule consists of a cyclic hexapeptide core containing the repetition of the D-Ala-L-Lys motif. The side chains of the lysine residues have been modified by appending the CD40L-derived sequence (143)Lys-Gly-Tyr-Tyr(146) via a 6-aminohexanoic acid residue as a spacer. The present report describes a general solid-phase synthesis approach to 1 and related trimeric architectures. In addition, their CD40 binding properties as well as their effector functions have been evaluated.

引用

页码：1461 / 1463

页数：3

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