Efforts toward the synthesis of (+)-Lyconadin A

被引：1

作者：

Karella, Satish ^{[1
,2
]}

Raghavan, Sadagopan ^{[1
,2
]}

机构：

[1] CSIR Indian Inst Chem Technol CSIR IICT, Dept Organ Synth & Proc Chem, Hyderabad 500007, Telangana, India

[2] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, Uttar Pradesh, India

来源：

JOURNAL OF CHEMICAL SCIENCES | 2020年 / 132卷 / 01期

关键词：

Lyconadin-A; 5-bromo-3-nicotinic acid; B-alkyl Suzuki coupling; intramolecular Michael reaction; LYCONADINS; REDUCTION; ALKALOIDS;

D O I：

10.1007/s12039-020-01771-8

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthetic efforts toward the synthesis of (+)-lyconadin A are described. B-Alkyl Suzuki coupling is utilized for combining 2-iodo cyclohexenone with the piperidine subunit. The piperidine subunit is derived from 5-bromo-3-nicotinic acid, and iodo cyclohexenone from commercially available (R)-pulegone. An intramolecular Michael reaction is employed for the creation of the C6-C7 bond. Graphic Synthetic efforts toward the synthesis of (+)-lyconadin A are described. B-Alkyl Suzuki coupling is utilized to combine 2-iodo cyclohexenone with the piperidine subunit. The piperidine subunit is derived from 5-bromo-3-nicotinic acid, and iodo cyclohexenone from commercially available (R)-pulegone. An intramolecular Michael reaction is employed for creation of the C6-C7 bond.

引用

页数：14

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