Thyroid Papillary Microtumor Validation of the (Updated) Porto Proposal Assessing Sex Hormone Receptor Expression and Mutational BRAF Gene Status

被引:22
作者
Aliyev, Elvin [1 ,7 ]
Ladra-Gonzalez, Maria J. [2 ]
Sanchez-Ares, Maria [1 ]
Abdulkader-Nallib, Ihab [1 ,5 ]
Piso-Neira, Magali [1 ]
Rodriguez-Carnero, Gemma [3 ]
Vieiro-Balo, Paula [1 ]
Perez-Becerra, Raquel [1 ]
Gude-Sampedro, Francisco [6 ]
Barreiro-Morandeira, Francisco [2 ,5 ]
Alvarez, Clara V. [4 ,5 ]
Cameselle-Teijeiro, Jose M. [1 ,5 ]
机构
[1] Clin Univ Hosp Santiago De Compostela, Galician Healthcare Serv SERGAS, Hlth Res Inst Santiago De Compostela IDIS, Dept Pathol, Santiago De Compostela, Spain
[2] Clin Univ Hosp Santiago De Compostela, Galician Healthcare Serv SERGAS, Hlth Res Inst Santiago De Compostela IDIS, Dept Surg, Santiago De Compostela, Spain
[3] Clin Univ Hosp Santiago De Compostela, Galician Healthcare Serv SERGAS, Hlth Res Inst Santiago De Compostela IDIS, Endocrinol & Nutr Div, Santiago De Compostela, Spain
[4] Hlth Res Inst Santiago De Compostela IDIS, Ctr Res Mol Med & Chron Dis CIMUS, Neoplasia & Endocrine Differentiat P0L5, Santiago De Compostela, Spain
[5] Univ Santiago De Compostela USC, Sch Med, Santiago De Compostela, Spain
[6] Clin Univ Hosp Santiago De Compostela, Hlth Res Inst Santiago De Compostela IDIS, Clin Epidemiol Unit, Santiago De Compostela, A Coruna, Spain
[7] Nakhchivan Autonomous Republ Hosp, Dept Surg, Nakhchivan, Nakhchivan Auto, Azerbaijan
关键词
papillary microcarcinoma; papillary microtumor; Porto proposal; thyroid cancer; sex hormone receptors; BRAF; ENCAPSULATED FOLLICULAR VARIANT; MODULATES CELL-GROWTH; ESTROGEN-RECEPTOR; NUCLEAR FEATURES; CLINICOPATHOLOGICAL FEATURES; ASSOCIATION GUIDELINES; PROGESTERONE-RECEPTOR; INCREASING INCIDENCE; RISK STRATIFICATION; ANDROGEN RECEPTORS;
D O I
10.1097/PAS.0000000000001522
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Given the high incidence and excellent prognosis of many papillary thyroid microcarcinomas, the Porto proposal uses the designation papillary microtumor (PMT) for papillary microcarcinomas (PMCs) without risk factors to minimize overtreatment and patients' stress. To validate Porto proposal criteria, we examined a series of 190 PMC series, also studying sex hormone receptors andBRAF(V600E)mutation. Our updated Porto proposal (uPp) reclassifies as PMT incidental PMCs found at thyroidectomy lacking the following criteria: (a) detected under the age of 19 years; (b) with multiple tumors measuring >1 cm adding up all diameters; and (c) with aggressive morphologic features (extrathyroidal extension, angioinvasion, tall, and/or hobnail cells). PMCs not fulfilling uPp criteria were considered "true" PMCs. A total of 102 PMCs were subclassified as PMT, 88 as PMC, with no age or sex differences between subgroups. Total thyroidectomy and iodine-131 therapy were significantly more common in PMC. After a median follow-up of 9.6 years, lymph node metastases, distant metastases, and mortality were only found in the PMC subgroup. No subgroup differences were found in calcifications or desmoplasia. Expression of estrogen receptor-alpha and estrogen receptor-beta, progesterone receptor, and androgen receptor was higher in PMC than in nontumorous thyroid tissue.BRAFmutations were detected in 44.7% of PMC, with no differences between subgroups. In surgical specimens, the uPp is a safe pathology tool to identify those PMC with extremely low malignant potential. This terminology could reduce psychological stress associated with cancer diagnosis, avoid overtreatment, and be incorporated into daily pathologic practice.
引用
收藏
页码:1161 / 1172
页数:12
相关论文
共 105 条
[1]   Integrated Genomic Characterization of Papillary Thyroid Carcinoma [J].
Agrawal, Nishant ;
Akbani, Rehan ;
Aksoy, B. Arman ;
Ally, Adrian ;
Arachchi, Harindra ;
Asa, Sylvia L. ;
Auman, J. Todd ;
Balasundaram, Miruna ;
Balu, Saianand ;
Baylin, Stephen B. ;
Behera, Madhusmita ;
Bernard, Brady ;
Beroukhim, Rameen ;
Bishop, Justin A. ;
Black, Aaron D. ;
Bodenheimer, Tom ;
Boice, Lori ;
Bootwalla, Moiz S. ;
Bowen, Jay ;
Bowlby, Reanne ;
Bristow, Christopher A. ;
Brookens, Robin ;
Brooks, Denise ;
Bryant, Robert ;
Buda, Elizabeth ;
Butterfield, Yaron S. N. ;
Carling, Tobias ;
Carlsen, Rebecca ;
Carter, Scott L. ;
Carty, Sally E. ;
Chan, Timothy A. ;
Chen, Amy Y. ;
Cherniack, Andrew D. ;
Cheung, Dorothy ;
Chin, Lynda ;
Cho, Juok ;
Chu, Andy ;
Chuah, Eric ;
Cibulskis, Kristian ;
Ciriello, Giovanni ;
Clarke, Amanda ;
Clayman, Gary L. ;
Cope, Leslie ;
Copland, John A. ;
Covington, Kyle ;
Danilova, Ludmila ;
Davidsen, Tanja ;
Demchok, John A. ;
DiCara, Daniel ;
Dhalla, Noreen .
CELL, 2014, 159 (03) :676-690
[2]  
Allred DC, 1998, MODERN PATHOL, V11, P155
[3]   Hobnail Variant of Papillary Thyroid Carcinoma: a Literature Review [J].
Ambrosi, Francesca ;
Righi, Alberto ;
Ricci, Costantino ;
Erickson, Lori A. ;
Lloyd, Ricardo V. ;
Asioli, Sofia .
ENDOCRINE PATHOLOGY, 2017, 28 (04) :293-301
[4]   Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): impact on the reclassification of thyroid nodules [J].
Amendoeira, Isabel ;
Maia, Tiago ;
Sobrinho-Simoes, Manuel .
ENDOCRINE-RELATED CANCER, 2018, 25 (04) :R247-R258
[5]  
[Anonymous], 2017, Cancer Staging Manual
[6]   Merits of the PMiT (Papillary Microtumor) Terminology in the Definition of a Subset of Incidental Papillary Microcarcinomas of the Thyroid [J].
Asioli, Sofia ;
Odasso, Chiara ;
Macri, Luigia ;
Palestini, Nicola ;
Bussolati, Gianni .
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, 2009, 17 (05) :378-383
[7]   Survival impact of psammoma body, stromal calcification, and bone formation in papillary thyroid carcinoma [J].
Bai, Yanhua ;
Zhou, Gengyin ;
Nakamura, Misa ;
Ozaki, Takashi ;
Mori, Ichiro ;
Taniguchi, Emiko ;
Miyauchi, Akira ;
Ito, Yasuhiro ;
Kakudo, Kennichi .
MODERN PATHOLOGY, 2009, 22 (07) :887-894
[8]   Thyroid papillary cancers: microcarcinoma and carcinoma, incidental cancers and non-incidental cancers - are they different diseases? [J].
Barbaro, D ;
Simi, U ;
Meucci, G ;
Lapi, P ;
Orsini, P ;
Pasquini, C .
CLINICAL ENDOCRINOLOGY, 2005, 63 (05) :577-581
[9]   Correlation between the BRAF V600E Mutation and Tumor Invasiveness in Papillary Thyroid Carcinomas Smaller than 20 Millimeters: Analysis of 1060 Cases [J].
Basolo, Fulvio ;
Torregrossa, Liborio ;
Giannini, Riccardo ;
Miccoli, Mario ;
Lupi, Cristiana ;
Sensi, Elisa ;
Berti, Piero ;
Elisei, Rossella ;
Vitti, Paolo ;
Baggiani, Angelo ;
Miccoli, Paolo .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (09) :4197-4205
[10]   Tall Cell Variant of Papillary Thyroid Microcarcinoma: Clinicopathologic Features with BRAFV600E Mutational Analysis [J].
Bernstein, Jane ;
Virk, Renu K. ;
Hui, Pei ;
Prasad, Avinash ;
Westra, William H. ;
Tallini, Giovanni ;
Adeniran, Adebowale J. ;
Udelsman, Robert ;
Sasaki, Clarence T. ;
Roman, Sanziana A. ;
Sosa, Julie A. ;
Prasad, Manju L. .
THYROID, 2013, 23 (12) :1525-1531