Palladium-Catalyzed One-Pot Consecutive Amination and Sonogashira Coupling for Selective Synthesis of 2-Alkynylanilines

被引：58

作者：

Pan, Shanfei ^{[1
]}

Ma, Xueji ^{[1
]}

Zhong, Danni ^{[1
]}

Chen, Wanzhi ^{[1
]}

Liu, Miaochang ^{[2
]}

Wu, Huayue ^{[2
]}

机构：

[1] Hangzhou Univ, Dept Chem, Hangzhou 310028, Zhejiang, Peoples R China

[2] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325027, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2015年 / 357卷 / 14-15期

关键词：

alkynols; 2-alkynylanilines; norbornene; palladium; tandem reactions; TOSYLHYDRAZONE INSERTION REACTION; C-H ACTIVATION; SUBSTITUTED ARYL IODIDES; ALPHA; ALPHA-DISUBSTITUTED ARYLMETHANOLS; EFFICIENT SYNTHESIS; INDOLE ALKALOIDS; BOND-CLEAVAGE; O-TERARYLS; SEQUENCE; ROUTE;

D O I：

10.1002/adsc.201500381

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An efficient catalytic approach to the synthesis of N,N-dialkyl-2-alkynylanilines was developed by using Pd-catalyzed norbornene-mediated three-component reactions of haloarenes, alkoxyamines (RO-NR2), and alkynes. The procedure forms one C N bond and one C C bond efficiently in a one-pot manner from readily available starting materials. A number of 2-alkynylanilines with a broad range of functional groups were afforded in good to excellent yields.

引用

页码：3052 / 3056

页数：5

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