The role of the thalamus in sleep, pineal melatonin production, and circadian rhythm sleep disorders

被引：159
作者：
Jan, James E. [1 ]
Reiter, Russel J. [2 ]
Wasdell, Michael B. [1 ]
Bax, Martin [3 ]
机构：
[1] BC Childrens Hosp, Melatonin Res Grp, Vancouver, BC V6H 3N1, Canada
[2] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA
[3] Univ London Imperial Coll Sci Technol & Med, London, England
来源：
JOURNAL OF PINEAL RESEARCH | 2009年 / 46卷 / 01期
关键词：
circadian rhythm sleep disorders; intergeniculate leaflet; melatonin; sleep gates; spindles; thalamus; PLACEBO-CONTROLLED TRIAL; FATAL FAMILIAL INSOMNIA; SUPRACHIASMATIC NUCLEUS; SPINDLE CHARACTERISTICS; ONSET INSOMNIA; CHILDREN; HUMANS; BRAIN; EEG; CONSOLIDATION;
D O I：
10.1111/j.1600-079X.2008.00628.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The thalamus has a strong nonphotic influence on sleep, circadian rhythmicity, pineal melatonin production, and secretion. The opening of the sleep gate for nonrapid eye movement sleep is a thalamic function but it is assisted by melatonin which acts by promoting spindle formation. Thus, melatonin has a modulatory influence on sleep onset and maintenance. A remarkable similarity exists between spindle behavior, circadian rhythmicity, and pineal melatonin production throughout life. Together, the thalamic and chronobiological control of sleep leads to a new and improved understanding of the pathophysiology of circadian rhythm sleep disorders and also of the principles of sleep hygiene interventions.
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页码：1 / 7
页数：7
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