Therapeutic areas of Li-ESWT in sexual medicine other than erectile dysfunction

被引：9
作者：
Fode, Mikkel [1 ]
Russo, Giorgio, I [2 ]
Verze, Paolo [3 ]
机构：
[1] Herlev & Gentofte Hosp, Dept Urol, Gentofte, Denmark
[2] Univ Catania, Dept Surg, Urol Sect, Catania, Italy
[3] Univ Naples Federico II, Dept Neurosci Sci Reprod & Odontostomatol, Naples, Italy
来源：
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH | 2019年 / 31卷 / 03期
关键词：
SHOCK-WAVE-THERAPY; MESENCHYMAL STEM-CELLS; PELVIC-PAIN-SYNDROME; ENDOTHELIAL PROGENITOR CELLS; PEYRONIES-DISEASE; NATURAL-HISTORY; DOUBLE-BLIND; DIFFERENTIATION; MANAGEMENT; TISSUE;
D O I：
10.1038/s41443-019-0114-2
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Low intensity extracorporal shock wave therapy (Li-ESWT) may induce tissue regeneration, neo-angiogenesis and improve endothelial function. This has shown promise in the treatment of erectile dysfunction (ED). The aim of this narrative review was to describe potential therapeutic areas of Li-ESWT in sexual medicine other than ED. An extensive literature search and review of the most recent guidelines revealed that Li-ESWT has been used in the treatment of Peyronie's disease (PD) and is being investigated as a method of improving stem cell therapy. In PD, Li-ESWT has been shown to decrease pain but no clinically relevant benefits regarding plaque size or penile curvature have been shown in randomized clinical trials. For stem cell optimization, only two preclinical studies have been conducted within the realm of sexual medicine. These show that application of Li-ESWT to the tissue after stem cell transplantation may increase the erectile response following cavernous nerve or diabetes damage. More research is needed to bring this concept from bench to bedside. In addition to this, Li-ESWT has shown promise in pelvic pain and it's effects on testicles have been preliminarily investigated in preclinical studies.
引用
收藏
页码：223 / 230
页数：8
相关论文
共 73 条
[1]   Treatment of Peyronie's disease by extracorporeal shockwave therapy: Evaluation of our preliminary results [J].
Abdel-Salam, Y ;
Budair, Z ;
Renner, C ;
Frede, T ;
Rassweiler, J ;
El-Annany, F ;
El-Magraby, H ;
El-Akkad, M .
JOURNAL OF ENDOUROLOGY, 1999, 13 (08) :549-552
[2]   Low-energy shock wave for enhancing recruitment of endothelial progenitor cells - A new modality to increase efficacy of cell therapy in chronic hind limb ischemia [J].
Aicher, Alexandra ;
Heeschen, Christopher ;
Sasaki, Ken-ichiro ;
Urbich, Carmen ;
Zeiher, Andreas M. ;
Dimmeler, Stefanie .
CIRCULATION, 2006, 114 (25) :2823-2830
[3]  
Al Edwan GM, 2017, ANN MED SURG, V14, P12, DOI 10.1016/j.amsu.2016.12.051
[4]   Peyronie's disease: a literature review on epidemiology, genetics, pathophysiology, diagnosis and work-up [J].
Al-Thakafi, Sultan ;
Al-Hathal, Naif .
TRANSLATIONAL ANDROLOGY AND UROLOGY, 2016, 5 (03) :280-289
[5]   Preliminary findings from a new animal model for Peyronie's disease involving extracorporeal shock waves [J].
Andrade, Enrico ;
Cortez, Italo ;
Claro, Joaquim ;
Pompeu, Eduardo ;
Leite, Katia ;
Paranhos, Mario ;
Borra, Priscila ;
Lucon, Antonio Marmo ;
Srougi, Miguel .
BJU INTERNATIONAL, 2009, 103 (08) :1104-1106
[6]   Low Intensity Extracorporeal Shock Wave Therapy Improves Erectile Function in a Model of Type II Diabetes Independently of NO/cGMP Pathway [J].
Assaly-Kaddoum, Rana ;
Giuliano, Francois ;
Laurin, Miguel ;
Gorny, Diane ;
Kergoat, Micheline ;
Bernabe, Jacques ;
Vardi, Yoram ;
Alexandre, Laurent ;
Behr-Roussel, Delphine .
JOURNAL OF UROLOGY, 2016, 196 (03) :950-956
[7]   Early effects of extracorporeal shock-wave lithotripsy exposure on testicular sperm morphology [J].
Basar, MM ;
Samli, MM ;
Erbil, M ;
Ozergin, O ;
Basar, R ;
Atan, A .
SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY, 2004, 38 (01) :38-41
[8]   The natural history of Peyronie's disease: An ultrasonography-based study [J].
Bekos, Athanasios ;
Aruaniti, Mary ;
Hatzimouratidis, Konstantinos ;
Moysidis, Kyriakos ;
Tzortzis, Vasilios ;
Hatzichristou, Dimitrios .
EUROPEAN UROLOGY, 2008, 53 (03) :644-651
[9]  
Bellorofonte C, 1989, Arch Ital Urol Nefrol Androl, V61, P417
[10]   Phase I and phase II clinical trials for the treatment of male sexual dysfunctiona systematic review of the literature [J].
Capogrosso, Paolo ;
Montorsi, Francesco ;
Salonia, Andrea .
EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2018, 27 (07) :583-593
12345678