Efficient synthesis of 2-amino-4-aryl-8-[(E)-arylmethylidene]-5, 6, 7, 8-4H pyrano [3, 2-c]pyridine in green media

被引：4

作者：

Balalaie, Saeed ^{[1
]}

Mehrazar, Mehrdad ^{[1
]}

Haghighatnia, Yaghoub ^{[1
]}

机构：

[1] KN Toosi Univ Technol, Peptide Chem Res Ctr, Tehran, Iran

来源：

GREEN CHEMISTRY LETTERS AND REVIEWS | 2013年 / 6卷 / 01期

关键词：

tetrahydro-4H-pyrano [3; 2-c]pyridine-3-carbonitriles; green media; diammonium hydrogen phosphate; piperidine; ring closure; atom-economy; condensation reaction; DIAMMONIUM HYDROGEN PHOSPHATE; ONE-POT SYNTHESIS; DIELS-ALDER REACTION; ORGANIC-REACTIONS; AQUEOUS-MEDIA; SOLVENT-FREE; WATER; DERIVATIVES; CYCLOADDITION; VERSATILE;

D O I：

10.1080/17518253.2012.709280

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient, general, and atom-economic procedure for the synthesis of 2-amino-6 methyl-4-aryl-8-[(E)-arylmethylidene]-5, 6, 7, 8-4H-pyrano [3, 2-c]pyridine-3-carbonitriles has been developed by reaction of 3,5-bis[(E)-arylmethylidene]-tetrahydro-4(1H)-pyridinones with malononitrile. The reaction proceeds under green media (EtOH/H2O, 1:1) and in the presence of diammonium hydrogen phosphate (10%) or piperidine (10%) to afford pyranopyridines at room temperature with good high yields. [GRAPHICS] .

引用

页码：101 / 105

页数：5

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