Hypoxia modulates innate immune factors: A review

被引：25

作者：

Mishra, K. P. ^{[1
]}

Ganju, Lilly ^{[1
]}

Singh, Shashi Bala ^{[1
]}

机构：

[1] Def Inst Physiol & Allied Sci, Immunomodulat Lab, Delhi 110054, India

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2015年 / 28卷 / 01期

关键词：

Hypoxia; Innate immunity; Phagocytosis; TLRs; Nitric oxide; NF-KAPPA-B; NITRIC-OXIDE SYNTHASE; ENDOTHELIAL-CELLS; LEUKOCYTE ADHESION; SIGNALING PATHWAYS; RECEPTOR; MACROPHAGES; EXPRESSION; INDUCTION; INJURY;

D O I：

10.1016/j.intimp.2015.07.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hypoxia is an important factor for transcriptional regulation of cell metabolism and the adaptation to cellular stress. It modulates the function of phagocytic cells by stimulating surface receptors such as scavenger receptors, toll like receptors and their downstream signaling cascades. In response to hypoxia, innate immune modifiers are upregulated through pathways involving the key immune response master regulator nuclear factor-kappa B leading to the modulation of inflammatory cytokines. In this review, we highlighted the effects of hypoxia on different innate immune factors and consequences thereof. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：425 / 428

页数：4

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