Transformation of p53-Positive Papillary Thyroid Carcinoma to Anaplastic Carcinoma of the Liver following Postoperative Radioactive Iodine-131 Therapy

被引：9

作者：

Takeshita, Yumie ^{[1
]}

Takamura, Toshinari ^{[1
]}

Minato, Hiroshi ^{[2
]}

Misu, Hirofumi ^{[1
]}

Ando, Hitoshi ^{[1
]}

Yamashita, Tatsuya ^{[1
]}

Ikeda, Hiroko ^{[3
]}

Nakanuma, Yasuni ^{[3
]}

Kaneko, Shuichi ^{[1
]}

机构：

[1] Kanazawa Univ, Grad Sch Med Sci, Dept Dis Control & Homeostasis, Kanazawa, Ishikawa, Japan

[2] Kanazawa Univ Hosp, Pathol Sect, Kanazawa, Ishikawa, Japan

[3] Kanazawa Univ, Grad Sch Med Sci, Dept Human Pathol, Kanazawa, Ishikawa, Japan

来源：

INTERNAL MEDICINE | 2008年 / 47卷 / 19期

关键词：

anaplastic transformation; differentiated thyroid carcinoma; iodine-131; therapy; p53; mutations; liver;

D O I：

10.2169/internalmedicine.47.1190

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Multiple liver metastases were incidentally detected in the lobe of the liver of an 81-year-old woman following total thyroidectomy and ablative radioactive iodine administration for the treatment of papillary thyroid carcinoma. A biopsy specimen taken from the metastatic liver tumor was histologically diagnosed as anaplastic carcinoma. Immunohistochemical staining for p53 was positive in both the primary tumor and liver biopsy specimens. We considered this to have been caused by anaplastic transformation from papillary thyroid carcinoma during treatment. We report a rare case of multiple liver metastases from a papillary thyroid carcinoma, which we believe to be the result of anaplastic transformation during postoperative radioactive iodine-131 therapy.

引用

页码：1709 / 1712

页数：4

共 22 条

[1] Treatment of anaplastic thyroid carcinoma with paclitaxel: Phase 2 trial using ninety-six-hour infusion
Ain, KB
Egorin, MJ
DeSimone, PA
[J]. THYROID, 2000, 10 (07) : 587 - 594
[2] Harada T, 1983, Nihon Geka Gakkai Zasshi, V84, P758
[3] ITO T, 1992, CANCER RES, V52, P1369
[4] KROKK TG, 2004, CANC TREAT RES, V122, P85
[5] MINJING Z, 1993, J CLIN ENDOCR METAB, V77, P1054
[6] RET oncogene amplification in thyroid cancer: correlations with radiation-associated and high-grade malignancy
Nakashima, Masahiro
Takamura, Noboru
Namba, Hiroyuki
Saenko, Vladimir
Meirmanov, Serik
Matsumoto, Naomichi
Hayashi, Tomayoshi
Maeda, Shigeto
Sekine, Ichiro
[J]. HUMAN PATHOLOGY, 2007, 38 (04) : 621 - 628
[7] NIEDERLE B, 1986, SURGERY, V100, P1088
[8] Overexpression of p53 protein and DNA content are important biologic prognostic factors for thyroid cancer
Nishida, T
Nakao, F
Hamaji, M
Nakahara, M
Tsujimoto, M
[J]. SURGERY, 1996, 119 (05) : 568 - 575
[9] OHWADA S, 1993, JPN J CLIN ONCOL, V23, P309
[10] Immunohistochemical localisation of RET and p53 mutant protein of thyroid lesions in a North-Eastern Malaysian population and its prognostic implications
Omar, E
Madhavan, M
Othman, NH
[J]. PATHOLOGY, 2004, 36 (02) : 152 - 159

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