The photoreactions of trimethoprim in solution

被引：12

作者：

Dedola, G ^{[1
]}

Fasani, E ^{[1
]}

Albini, A ^{[1
]}

机构：

[1] Univ Pavia, Dipartimento Chim Organ, I-27100 Pavia, Italy

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY | 1999年 / 123卷 / 1-3期

关键词：

trimethoprim; drugs photoreactivity; drugs photolability; type I and II photooxidation;

D O I：

10.1016/S1010-6030(99)00047-7

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The photochemical behaviour of Trimethoprim, a trimethoxybenzylpyrimidine used as bactericide, in solution has been investigated. Direct irradiation causes a slow reaction (e.g. Phi in methanol 3 x 10(-4)). The molecule is quite sensitive to benzylic hydrogen abstraction by n pi* ketones yielding dimers in;the absence of oxygen or oxidised products (the corresponding benzoylpyrimidine and trimethoxybenzaldehyde) in its presence. The drug is also sensitive to singlet oxygen, likewise undergoing oxidative cleavage, though inefficiently. The reported photolability of drug preparations is probably due to sensitised oxidation by impurities or other components. (C) 1999 Elsevier Science S.A. All rights reserved.

引用

页码：47 / 51

页数：5