Endoscopic imaging of Cerenkov luminescence

被引：45

作者：

Kothapalli, Sri-Rajasekhar ^{[1
,2
]}

Liu, Hongguang ^{[1
,2
]}

Liao, Joseph C. ^{[3
,4
]}

Cheng, Zhen ^{[1
,2
]}

Gambhir, Sanjiv Sam ^{[1
,2
,5
]}

机构：

[1] Stanford Univ, Dept Radiol, Mol Imaging Program Stanford, Palo Alto, CA 94304 USA

[2] Stanford Univ, Biox Program, Palo Alto, CA 94304 USA

[3] Stanford Univ, Dept Urol, Palo Alto, CA 94304 USA

[4] Vet Affairs Palo Alto Hlth Care Syst, Palo Alto, CA USA

[5] Stanford Univ, Dept Mat Sci & Engn, Dept Bioengn, Palo Alto, CA 94304 USA

来源：

BIOMEDICAL OPTICS EXPRESS | 2012年 / 3卷 / 06期

关键词：

POSITRON-EMISSION-TOMOGRAPHY; CANCER; PET; PROSTATE; HYPOXIA; DISEASE; BLADDER; LIGHT;

D O I：

10.1364/BOE.3.001215

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We demonstrate feasibility of endoscopic imaging of Cerenkov light originated when charged nuclear particles, emitted from radionuclides, travel through a biological tissue of living subjects at superluminal velocity. The endoscopy imaging system consists of conventional optical fiber bundle/ clinical endoscopes, an optical imaging lens system, and a sensitive low-noise charge coupled device (CCD) camera. Our systematic studies using phantom samples show that Cerenkov light from as low as 1 mu Ci of radioactivity emitted from F-18-Fluorodeoxyglucose (FDG) can be coupled and transmitted through conventional optical fibers and endoscopes. In vivo imaging experiments with tumor bearing mice, intravenously administered with F-18-FDG, further demonstrated that Cerenkov luminescence endoscopy is a promising new tool in the field of endoscopic molecular imaging. (C) 2012 Optical Society of America

引用

页码：1215 / 1225

页数：11

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