Protection of MLV vector particles from human complement

被引：11
作者：
Breun, S
Salmons, B
Günzburg, WH
Baumann, JG
机构：
[1] Univ Vet Sci, Inst Virol, A-1210 Vienna, Austria
[2] Bavarian Nord Res Inst GmbH, D-82152 Martinsried, Germany
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1999年 / 264卷 / 01期
关键词：
D O I：
10.1006/bbrc.1999.1474
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Murine cell-derived MLV vector particles usually are highly sensitive to human complement-mediated lysis. Expression of the human complement inhibitor CD59 on murine packaging cells resulted in partial protection of these cells from lysis caused by human complement proteins. Furthermore, CD59 was incorporated into MLV vector particles released by these packaging cells, leading to an improved resistance of the virions against human complement-mediated inactivation. (C) 1999 Academic Press.
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页码：1 / 5
页数：5
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