Angiopoietin-like proteins in multiple sclerosis

被引：4

作者：

Al-Temaimi, Rabeah ^{[1
]}

Cherian, Preethi ^{[2
]}

Abu-Farha, Mohamed ^{[2
]}

Alroughani, Raed ^{[3
]}

机构：

[1] Kuwait Univ, Fac Med, Dept Pathol, Human Genet Unit, POB 24923, Safat 13110, Kuwait

[2] Dasman Diabet Inst, Biochem & Mol Biol Unit, Kuwait, Kuwait

[3] Amiri Hosp, Dept Med, Div Neurol, Kuwait, Kuwait

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2019年 / 330卷

关键词：

Multiple sclerosis; Angiopoietin-like proteins; Natalizumab; Fingolimod; GROWTH-FACTOR; BRAIN; RISK;

D O I：

10.1016/j.jneuroim.2019.02.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Angiopoietin-like proteins (ANGPTLs) are a group of proteins with functions in lipid metabolism, angiogenesis, and inflammation. Here, we investigated their involvement in multiple sclerosis (MS) progression and response to treatment in 100 MS patients and 77 healthy controls. ANGPTLs significantly associated with MS progression and response to therapy. High ANGPTL6 levels associated with slow disease progression and good response to fingolimod treatment and low ANGPTL4 associated with poor response to natalizumab treatment. Therefore, we propose high ANGPTL4 and 6 levels as markers for positive response to MS treatments either natalizumab or fingolimod respectively. Further investigations into their role in MS is warranted.

引用

页码：31 / 34

页数：4

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