Rapid detection of Cu2+ by a paper-based microfluidic device coated with bovine serum albumin (BSA)-Au nanoclusters

被引：30

作者：

Fang, Xueen ^{[1
,2
,3
]}

Zhao, Qianqian ^{[1
,2
]}

Cao, Hongmei ^{[1
,2
]}

Liu, Juan ^{[1
,2
]}

Guan, Ming ^{[1
,2
]}

Kong, Jilie ^{[1
,2
]}

机构：

[1] Fudan Univ, Shanghai Med Coll, Huashan Hosp, Dept Chem, Shanghai 200433, Peoples R China

[2] Fudan Univ, Shanghai Med Coll, Huashan Hosp, Dept Lab Med, Shanghai 200433, Peoples R China

[3] Shanghai Suxin Biotech Co Ltd, Shanghai 200443, Peoples R China

来源：

ANALYST | 2015年 / 140卷 / 22期

基金：

中国国家自然科学基金;

关键词：

QUANTUM DOTS; FLUORESCENT CHEMOSENSOR; COPPER-ION; NANOPARTICLES; CONJUGATE;

D O I：

10.1039/c5an01016k

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In this work, bovine serum albumin (BSA)-Au nanoclusters were used to coat a paper-based microfluidic device. This device acted as a Cu2+ biosensor that showed fluorescence quenching on detection of copper ions. The detection limit of this sensor could be adjusted by altering the water absorbing capacity of the device. Qualitative and semi-quantitative results could be obtained visually without the aid of any advanced instruments. This sensor could test Cu2+ rapidly with high specificity and sensitivity, which would be useful for point-of-care testing (POCT).

引用

页码：7823 / 7826

页数：4

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