A critical role for phospholipase C in protective immunity conferred by listeriolysin O-deficient Listeria monocytogenes

被引：10

作者：

Orgun, Nural N. ^{[1
]}

Way, Sing Sing ^{[1
]}

机构：

[1] Univ Minnesota, Dept Pediat & Microbiol, Ctr Infect Dis & Microbiol Translat Res, Sch Med, Minneapolis, MN 55455 USA

来源：

MICROBIAL PATHOGENESIS | 2008年 / 44卷 / 02期

关键词：

Bacteria; Vaccine; T cell immunity;

D O I：

10.1016/j.micpath.2007.08.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Attenuated recombinant Listeria monocytogenes (Lm) strains are a promising class of vaccine vectors that trigger protective antigen-specific CD8 T cells. Listeriolysin 0 (LLO) is an important Lm virulence determinant allowing the bacterium to escape from the endocytic vacuole into the cell cytoplasm in phagocytic cells. However in non-phagocytic cells, Lm phospholipase C can also mediate cytoplasmic entry. The ability of LLO-deficient Lm to confer long-term protection to infection is uncertain. Herein, we demonstrate that LLO-deficient Lm mutants can prime protective immunity to subsequent Lm infection and that Lm phospholipase C is required for protective immunity conferred by LLO-deficient Lm. (C) 2007 Elsevier Ltd. All rights reserved.

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收藏

页码：159 / 163

页数：5

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