Chemical Methods for Probing Virus-Host Proteomic Interactions

被引：7

作者：

Strmiskova, Miroslava ^{[1
]}

Desrochers, Genevieve F. ^{[1
]}

Shaw, Tyler A. ^{[1
]}

Powdrill, Megan H. ^{[1
]}

Lafreniere, Matthew A. ^{[1
]}

Pezacki, John Paul ^{[1
]}

机构：

[1] Univ Ottawa, Dept Chem & Biomol Sci, Ctr Chem & Synthet Biol, 10 Marie Curie Private, Ottawa, ON K1N 6N5, Canada

来源：

ACS INFECTIOUS DISEASES | 2016年 / 2卷 / 11期

基金：

加拿大自然科学与工程研究理事会;

关键词：

chemoproteomics; activity-based protein profiling; quantitative proteomics; protein interactions; ACTIVITY-BASED PROBES; FATTY-ACID SYNTHASE; QUANTITATIVE PROTEOMICS; DENGUE VIRUS; ANTIVIRAL ACTIVITY; BETA-LACTAMS; IN-VIVO; PHOTOAFFINITY PROBES; RESPONSE FACTOR; HEPATOMA-CELLS;

D O I：

10.1021/acsinfecdis.6b00084

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Interactions between host and pathogen proteins constitute an important aspect of both infectivity and the host immune response. Different viruses have evolved complex mechanisms to hijack host-cell machinery and metabolic pathways to redirect resources and energy flow toward viral propagation. These interactions are often critical to the virus, and thus understanding these interactions at a molecular level gives rise to opportunities to develop novel antiviral strategies for therapeutic intervention. This review summarizes current advances in chemoproteomic methods for studying these molecular altercations between different viruses and their hosts.

引用

页码：773 / 786

页数：14

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