THE NEURONAL CELL CYCLE AS A MECHANISM OF PATHOGENESIS IN ALZHEIMER'S DISEASE

被引：0

作者：

Currais, Antonio ^{[1
]}

Malik, Bilal ^{[1
]}

Hortobagyi, Tibor ^{[2
,3
]}

Soriano, Salvador ^{[1
]}

机构：

[1] Kings Coll London, Inst Psychiat, MRC Ctr Neurodegenerat Res, Dept Neurosci, London SE5 8AF, England

[2] Univ Szeged, Dept Pathol, Szeged, Hungary

[3] Kings Coll Hosp London, Acad Neurosci Ctr, Dept Clin Neuropathol, London, England

来源：

ZDRAVNISKI VESTNIK-SLOVENIAN MEDICAL JOURNAL | 2008年 / 77卷

关键词：

Alzheimer's disease; cell cycle; neurodegeneration; apoptosis; catenin; presenilins;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Differentiated neurons display specific biochemical, physiological and morphological properties that apparently prevent them from further cell division. Nevertheless, expression of cell cycle modulators persists after neuronal differentiation and is upregulated under stress conditions, such as trophic factor deprivation, oxidative stress and the presence of DNA damaging agents. This apparent reactivation of the cell cycle has been postulated as a sine qua non for neuronal death in response to those stress conditions, particularly in Alzheimer's disease. However, the physiological and pathogenic implications of a putative neuronal cell cycle are far from clear. Here, we discuss the notion of the neuronal cell cycle as a mediator of cell death in Alzheimer's disease.

引用

页码：II13 / II20

页数：8

共 68 条

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