Integrins as regulators of the mitotic machinery

被引：32

作者：

LaFlamme, Susan E. ^{[1
]}

Nieves, Bethsaida ^{[1
]}

Colello, Diane ^{[1
]}

Reverte, Carlos G. ^{[2
]}

机构：

[1] Albany Med Coll, Ctr Cell Biol & Canc Res, Albany, NY 12208 USA

[2] Vassar Coll, Dept Biol, Poughkeepsie, NY 12604 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2008年 / 20卷 / 05期

关键词：

D O I：

10.1016/j.ceb.2008.06.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitotic spindle bipolarity defines a unique division plane that promotes the successful transmission of genetic material during cytokinesis. The positioning and orientation of the spindle determines the symmetry of cell division and the relative location of daughter cells, which regulate cell fate decisions that contribute to embryonic development and tissue differentiation. Recent studies have identified integrins as regulators of spindle positioning and orientation, as well as spindle bipolarity and cytokinesis. This review summarizes and discusses the current effort focused on understanding how integrins regulate these mitotic events.

引用

页码：576 / 582

页数：7

共 61 条

[1] Tracking the ends: a dynamic protein network controls the fate of microtubule tips [J].

Akhmanova, Anna ;

Steinmetz, Michel O. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2008, 9 (04) :309-322

[2] Src kinase activation by direct interaction with the integrin β cytoplasmic domain [J].

Arias-Salgado, EG ;

Lizano, S ;

Sarkar, S ;

Brugge, JS ;

Ginsberg, MH ;

Shattil, SJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (23) :13298-13302

[3] β1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis [J].

Aszodi, A ;

Hunziker, EB ;

Brakebusch, C ;

Fässler, R .

GENES & DEVELOPMENT, 2003, 17 (19) :2465-2479

[4] Cytokinesis: Placing and making the final cut [J].

Barr, Francis A. ;

Gruneberg, Ulrike .

CELL, 2007, 131 (05) :847-860

[5] The integrin β tail is required and sufficient to regulate adhesion signaling to Rac1 [J].

Berrier, AL ;

Martinez, R ;

Bokoch, GM ;

LaFlamme, SE .

JOURNAL OF CELL SCIENCE, 2002, 115 (22) :4285-4291

[6] Activated R-Ras, Rac1, PI 3-kinase and PKC∈ can each restore cell spreading inhibited by isolated integrin β1 cytoplasmic domains [J].

Berrier, AL ;

Mastrangelo, AM ;

Downward, J ;

Ginsberg, M ;

LaFlamme, SE .

JOURNAL OF CELL BIOLOGY, 2000, 151 (07) :1549-1560

[7] Cell-matrix adhesion [J].

Berrier, Allison L. ;

Yamada, Kenneth M. .

JOURNAL OF CELLULAR PHYSIOLOGY, 2007, 213 (03) :565-573

[8]

Bodeau AL, 2001, J CELL SCI, V114, P2795

[9] APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice [J].

Caldwell, Christine M. ;

Green, Rebecca A. ;

Kaplan, Kenneth B. .

JOURNAL OF CELL BIOLOGY, 2007, 178 (07) :1109-1120

[10] The phosphoinositide 3-kinase pathway [J].

Cantley, LC .

SCIENCE, 2002, 296 (5573) :1655-1657

← 1 2 3 4 5 6 7 →