Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product Calcipressin 1 (or RCAN1) in disease

被引：98

作者：

Harris, CD ^{[1
]}

Ermak, G ^{[1
]}

Davies, KJA ^{[1
]}

机构：

[1] Univ So Calif, Ethel Percy Andrus Gerontol Ctr, Los Angeles, CA 90089 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2005年 / 62卷 / 21期

关键词：

Down syndrome; Alzheimer's disease; cardiac hypertrophy; calcineurin; calcipressin; 1; MCIP1; DSCR1; Adapt78; RCAN1;

D O I：

10.1007/s00018-005-5085-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The DSCR1 (Adapt78) gene(1) is transiently induced by stresses to temporarily protect cells against further potentially lethal challenges. However, chronic expression of the DSCR1 (Adapt78) gene has now been implicated in several pathological conditions including Alzheimer's disease, Down syndrome and cardiac hypertrophy. Calcipressin 1 has been shown to function through direct binding and inhibition of the serine threonine protein phosphatase Calcineurin. Pharmacological inhibition of calcineurin, by the immunosuppressive drugs cyclosporin A and FK506, affects a wide variety of diseases. It is, therefore, likely that this endogenous calcineurin inhibitor, calcipressin 1, may also play a role in a variety of human diseases.

引用

页码：2477 / 2486

页数：10

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