Histiocytic sarcoma of the brain

被引：21

作者：

Gill-Samra, Spinderjeet ^{[1
]}

Ng, Thomas ^{[1
,7
]}

Dexter, Mark ^{[2
]}

Wong, Mark ^{[3
]}

Nahar, Najmun ^{[4
]}

Allsopp, Katherine ^{[5
]}

Boadle, Rose A. ^{[6
]}

Varikatt, Winny ^{[1
,7
]}

机构：

[1] Westmead Hosp, Dept Tissue Pathol, ICPMR, Westmead, NSW 2145, Australia

[2] Westmead Hosp, Dept Neurosurg, Westmead, NSW 2145, Australia

[3] Westmead Hosp, Dept Med Oncol, Westmead, NSW 2145, Australia

[4] Westmead Hosp, Dept Radiat Oncol, Westmead, NSW 2145, Australia

[5] Westmead Hosp, Dept Palliat Care, Westmead, NSW 2145, Australia

[6] Westmead Hosp, Dept Tissue Pathol, Electron Microscope Lab, Westmead, NSW 2145, Australia

[7] Univ Western Sydney, Sch Med, Penrith, NSW 1797, Australia

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2012年 / 19卷 / 10期

关键词：

Brain; Histiocytic sarcoma; Lympho-hematopoietic; Malignant tumour; CENTRAL-NERVOUS-SYSTEM; LYMPHOMA; NEOPLASM;

D O I：

10.1016/j.jocn.2011.10.023

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Histiocytic sarcoma is a rare malignant neoplasm of the lympho-hematopoietic system that usually occurs in the skin, lymph nodes and intestinal tract. We present a 36-year-old woman with a rare histiocytic sarcoma with isolated central nervous system (CNS) involvement of multifocal circumscribed lesions. Biopsy of the brain lesions showed diffuse proliferation of pleomorphic histiocytes that were immunopositive for CD45, CD68 and CD163. Various cytokeratins and markers of lymphoma, melanoma, germ cell tumours and primary CNS tumours were negative. Examination of bone marrow trephine and a whole-body positron emission tomography scan showed no evidence of involvement of any other organ systems, thus establishing the primary nature of the lesion. The neoplastic cells uniquely showed eosinophilic globules within the cytoplasm, which were positive for CD68. These globules were shown by electron microscopy to be collections of lysosomes. A thorough discussion of the differential diagnosis and literature review is included. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1456 / 1458

页数：3

共 14 条

[1]

Cao M, 2007, ARCH PATHOL LAB MED, V131, P301

[2] Primary histiocytic lymphoma of the central nervous system - A neoplasm frequently overshadowed by a prominent inflammatory component [J].

Cheuk, W ;

Walford, N ;

Lou, J ;

Lee, AKC ;

Fung, CF ;

An, KH ;

Mak, LS ;

Chan, JKC .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2001, 25 (11) :1372-1379

[3] Histiocytic sarcoma localised in the thyroid - a case report [J].

De Vos, Filip Y. F. L. ;

Gerding, Martin N. ;

Arends, Jan W. ;

Wegman, Jurgen J. .

ANNALS OF HEMATOLOGY, 2008, 87 (08) :681-682

[4] A CLINICOPATHOLOGICALLY DISTINCTIVE PRIMARY SPLENIC HISTIOCYTIC NEOPLASM - DEMONSTRATION OF ITS HISTIOCYTIC DERIVATION BY IMMUNOPHENOTYPIC AND MOLECULAR GENETIC-ANALYSIS [J].

FRANCHINO, C ;

REICH, C ;

DISTENFELD, A ;

UBRIACO, A ;

KNOWLES, DM .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1988, 12 (05) :398-404

[5]

Jaffe ES, 2008, WHO CLASSIFICATION T, P354

[6] 2 VARIETIES OF LYMPHOID TISSUE RETICULOSARCOMAS, HISTIOCYTIC AND HISTIOBLASTIC TYPES [J].

MATHE, G ;

GERARDMA.R ;

TEXIER, JL ;

SCHLUMBERGER, JR ;

BERUMEN, L ;

PAINTRAND, M .

BRITISH JOURNAL OF CANCER, 1970, 24 (04) :687-+

[7] TRUE HISTIOCYTIC LYMPHOMA WITH MULTIPLE SKIN NODULES [J].

OSBORNE, BM ;

MACKAY, B .

ULTRASTRUCTURAL PATHOLOGY, 1994, 18 (1-2) :241-246

[8] Tumours of histiocytes and accessory dendritic cells:: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases [J].

Pileri, SA ;

Grogan, TM ;

Harris, NL ;

Banks, P ;

Campo, E ;

Chan, JKC ;

Favera, RD ;

Delsol, G ;

De Wolf-Peeters, C ;

Falini, B ;

Gascoyne, RD ;

Gaulard, P ;

Gatter, KC ;

Isaacson, PG ;

Jaffe, ES ;

Kluin, P ;

Knowles, DM ;

Mason, DY ;

Mori, S ;

Müller-Hermelink, HK ;

Piris, MA ;

Ralfkiaer, E ;

Stein, H ;

Su, IJ ;

Warnke, RA ;

Weiss, LM .

HISTOPATHOLOGY, 2002, 41 (01) :1-29

[9]

Seo IS, 1999, ULTRASTRUCT PATHOL, V23, P333

[10] Histiocytic sarcoma involving the central nervous system - Clinical, immunohistochemical, and molecular genetic studies of a case with review of the literature [J].

Sun, W ;

Nordberg, ML ;

Fowler, MR .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2003, 27 (02) :258-265

← 1 2 →