Local and systemic bone effects of rheumatoid arthritis

被引：0
作者：
Rauner, M. [1 ]
Hofbauer, L. C. [1 ]
Aringer, M. [2 ]
机构：
[1] Tech Univ Dresden, Univ Klinikum Carl Gustav Carus, Med Klin & Poliklin 3, Bereich Endokrinol, D-01307 Dresden, Germany
[2] Tech Univ Dresden, Univ Klinikum Carl Gustav Carus, Med Klin & Poliklin 3, Bereich Rheumatol, D-01307 Dresden, Germany
来源：
ZEITSCHRIFT FUR RHEUMATOLOGIE | 2012年 / 71卷 / 10期
关键词：
Rheumatoid arthritis; Osteoporosis; Cytokines; Glucocorticoids; Osteolysis; essential; VITAMIN-D; DOUBLE-BLIND; OSTEOCLAST FORMATION; MONOCLONAL-ANTIBODY; DISEASE-ACTIVITY; MINERAL DENSITY; RECEPTOR; METHOTREXATE; INHIBITION; INTERLEUKIN-6;
D O I：
10.1007/s00393-011-0927-y
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Rheumatoid arthritis (RA) is a bone-destructive disease that is a serious risk factor for the development of osteoporosis, which is defined by a loss in bone quality and an increased fracture risk. The proinflammatory cytokines tumor necrosis factor-alpha (TNF alpha), interleukin-6 (IL-6) and IL-17, in particular, contribute to local and systemic bone loss in RA. While effectively reducing inflammation, glucocorticoids add to the fracture risk. Therefore, an adequate supply of calcium and vitamin D is essential. For many patients with RA, bone density measurements are recommended.
引用
收藏
页码：869 / 873
页数：5
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