Pharmacological treatments for functional nausea and functional dyspepsia in children: a systematic review

被引:38
作者
Browne, Pamela D. [1 ]
Nagelkerke, Sjoerd C. J. [1 ]
van Etten-Jamaludin, Faridi S. [2 ]
Benninga, Marc A. [1 ]
Tabbers, Merit M. [1 ]
机构
[1] Univ Amsterdam, Amsterdam UMC, Emma Childrens Hosp, Pediat Gastroenterol, Amsterdam, Netherlands
[2] Univ Amsterdam, Amsterdam UMC, Res Support, Med Lib, Amsterdam, Netherlands
关键词
Children; functional dyspepsia; functional nausea; pharmacological treatment; systematic review; PROTON-PUMP INHIBITORS; GASTRIC SENSORIMOTOR FUNCTION; IRRITABLE-BOWEL-SYNDROME; GASTROINTESTINAL DISORDERS; ABDOMINAL-PAIN; DOUBLE-BLIND; GASTROESOPHAGEAL-REFLUX; BACTERIAL OVERGROWTH; CLINICAL-TRIALS; EFFICACY;
D O I
10.1080/17512433.2018.1540298
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Introduction: Chronic idiopathic nausea (CIN) and functional dyspepsia (FD) cause considerable strain on many children's lives and their families. Areas covered: This study aims to systematically assess the evidence on efficacy and safety of pharmacological treatments for CIN or FD in children. CENTRAL, EMBASE, and Medline were searched for Randomized Controlled Trials (RCTs) investigating pharmacological treatments of CIN and FD in children (4-18 years). Cochrane risk of bias tool was used to assess methodological quality of the included articles. Expert commentary: Three RCTs (256 children with FD, 2-16 years) were included. No studies were found for CIN. All studies showed considerable risk of bias, therefore results should be interpreted with caution. Compared with baseline, successful relief of dyspeptic symptoms was found for omeprazole (53.8%), famotidine (44.4%), ranitidine (43.2%) and cimetidine (21.6%) (p = 0.024). Compared with placebo, famotidine showed benefit in global symptom improvement (OR 11.0; 95% CI 1.6-75.5; p = 0.02). Compared with baseline, mosapride versus pantoprazole reduced global symptoms (p = 0.011; p = 0.009). One study reported no occurrence of adverse events. This systematic review found no evidence to support the use of pharmacological drugs to treat CIN or FD in children. More high-quality clinical trials are needed.
引用
收藏
页码:1195 / 1208
页数:14
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