Synthesis of poly(vinyl acetate)-based magnetic polymer microparticles

被引：36
作者：
Ferreira, Gabriella R. [1 ]
Segura, Tayana [2 ]
de Souza, Fernando G., Jr. [2 ]
Umpierre, Alexandre P. [1 ]
Machado, Fabricio [1 ]
机构：
[1] Univ Brasilia, Inst Quim, BR-70904970 Brasilia, DF, Brazil
[2] Univ Fed Rio de Janeiro, Inst Macromol Professora Eloisa Mano IMA UFRJ, BR-21945970 Rio De Janeiro, Brazil
来源：
EUROPEAN POLYMER JOURNAL | 2012年 / 48卷 / 12期
关键词：
Intravascular embolization; Hyperthermia; Vinyl acetate; Fe3O4 magnetic nanoparticles; Suspension polymerization; Core-shell polymer particles; HETEROGENEOUS SURFACE SAPONIFICATION; BATCH SUSPENSION POLYMERIZATION; MAGHEMITE NANOPARTICLES; VINYL-ACETATE; IRON-OXIDE; MICROSPHERES; PARTICLES; COMPOSITE; ALCOHOL); NANOCOMPOSITES;
D O I：
10.1016/j.eurpolymj.2012.09.003
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
This work provides details on the synthesis of poly(vinyl acetate)/poly(vinyl alcohol) intended for medical applications such as intravascular embolization procedures and hyperthermia treatment of injured areas. The proposed method showed to-be very efficient for the synthesis of micro-sized magnetic particles. The hydrolyzed polymeric material presented thermal stability higher than that observed in pure poly(vinyl acetate) particle and the magnetic polymeric materials exhibited better thermal stability. It was also shown that the morphology of the precursor poly(vinyl acetate) is preserved when mild reaction conditions (temperature and alkoxide concentration) are adopted during the hydrolysis reaction. Furthermore, it was noticed that Na2SO4 promotes morphological control, minimizing the solubility of poly(vinyl acetate) in methanol and poly(vinyl alcohol) in water. DSC analyses showed that polymer particles with core-shell type morphology were properly obtained, exhibiting two distinct glass transition temperatures, characterized by the presence of pure poly(vinyl alcohol) in the shell and pure poly(vinyl acetate) in the core of the particles. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2050 / 2069
页数：20
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