Fuller's earth catalyzed rapid synthesis of bis(indolyl)methanes under solvent free condition

被引：0

作者：

Kapuriya, Naval ^{[1
]}

Kakadiya, Rajesh ^{[1
]}

Savant, Mahesh M. ^{[1
]}

Pansuriya, Akshay M. ^{[1
]}

Bhuva, Chirag V. ^{[1
]}

Patel, Anil S. ^{[1
]}

Pipaliya, Piyush V. ^{[1
]}

Audichya, Vipul B. ^{[1
]}

Gangadharaiah, Sarala ^{[2
]}

Anandalwar, Sridhar M. ^{[2
]}

Prasad, Javaregowda S. ^{[2
]}

Shah, Anamik ^{[1
]}

Naliapara, Yogesh T. ^{[1
]}

机构：

[1] Saurashtra Univ, Dept Chem, Chem Res Lab, Rajkot 360005, Gujarat, India

[2] Univ Mysore, Dept Studies Phys, Mysore 570006, Karnataka, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2012年 / 51卷 / 07期

关键词：

Fuller's earth; electrophilic addition; bis(indolyl)-methanes; water mediated; solvent free condition; NATURAL KAOLINITIC CLAY; REUSABLE SOLID CATALYST; ELECTROPHILIC SUBSTITUTION; CARBONYL-COMPOUNDS; EXPEDIENT SYNTHESIS; EFFICIENT SYNTHESIS; BIS-INDOLYLMETHANE; 3-ACETYL INDOLES; HYDROGEN SULFATE; FACILE SYNTHESIS;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A rapid and highly efficient synthesis of various bis(indolyl)methanes with high yield by the reaction of indoles 1a-c and arylaldehydes 2a'-m' in presence of fuller's earth is demonstrated. This simple and versatile protocol is found to be an efficient catalyst for the electrophilic addition reaction of indole and works well under solvent free condition as well as in aqueous medium. The structure of newly synthesized compound 3m has been confirmed by single crystal X-ray crystallography.

引用

页码：1032 / 1038

页数：7

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