Naphtho-γ-pyrones from Endophyte Aspergillus niger Occurring in the Liverwort Heteroscyphus tener (STEPH.) SCHIFFN.

被引：42

作者：

Li, Xiao-Bin ^{[1
]}

Xie, Fei ^{[1
]}

Liu, Shan-Shan ^{[1
]}

Li, Ying ^{[1
]}

Zhou, Jin-Chuan ^{[1
]}

Liu, Yong-Qing ^{[2
]}

Yuan, Hui-Qing ^{[2
]}

Lou, Hong-Xiang ^{[1
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Chem Biol,Dept Nat Prod Chem, Jinan 250012, Peoples R China

[2] Shandong Univ, Sch Med, Dept Biochem & Mol Biol, Jinan 250012, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2013年 / 10卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Aspergillus niger; Fungi; Naphtho--pyrones; Malformin A(1); Cytotoxic activity; NATURAL-PRODUCTS; AURASPERONE; METABOLITES; INHIBITION; GROWTH; FUNGUS;

D O I：

10.1002/cbdv.201300042

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bioactivity-guided fractionation of the cytotoxic extract of Aspergillus niger, an endophytic fungus from the Chinese liverwort Heteroscyphus tener (Steph.) Schiffn., afforded five new naphtho--pyrones, rubrofusarin-6-O--D-ribofuranoside (1), (R)-10-(3-succinimidyl)-TMC-256A1 (2), asperpyrone E (3), isoaurasperone A (4), and isoaurasperone F (5), as well as four known ones, dianhydroaurasperone C (6), aurasperone D (7), asperpyrone D (8), and asperpyrone A (9), together with a cytotoxic cyclic pentapeptide, malformin A(1) (10). Their structures were determined by extensive spectroscopic analysis. The absolute configurations of dimeric naphtho--pyrones 3-9 were also determined by analysis of their respective CD spectra.

引用

页码：1193 / 1201

页数：9

共 33 条

[1] New dimeric naphthopyrones from Aspergillus niger [J].

Akiyama, K ;

Teraguchi, S ;

Hamasaki, Y ;

Mori, M ;

Tatsumi, K ;

Ohnishi, K ;

Hayashi, H .

JOURNAL OF NATURAL PRODUCTS, 2003, 66 (01) :136-139

[2] Aurasperone F -: a new member of the naphtho-gamma-pyrone class isolated from a cultured microfungus, Aspergillus niger C-433 [J].

Bouras, N ;

Mathieu, F ;

Coppel, Y ;

Lebrihi, A .

NATURAL PRODUCT RESEARCH, 2005, 19 (07) :653-659

[3] Spectral assignments and reference data -: Complete 1H and 13C NMR assignments of aurasperone A and fonsecinone A, two bis-naphthopyrones produced by Aspergillus aculeatus [J].

Campos, FR ;

Barison, A ;

Daolio, C ;

Ferreira, AG ;

Rodrigues-Fo, E .

MAGNETIC RESONANCE IN CHEMISTRY, 2005, 43 (11) :962-965

[4] PHYTOCHROME INVOLVEMENT IN STIMULATION AND ALLEVIATION OF INHIBITION OF PLANT-GROWTH BY MALFORMIN [J].

CURTIS, RW .

PLANT PHYSIOLOGY, 1977, 60 (04) :622-624

[5]

Franck V. B., 1984, ANGEW CHEM, V96, P462

[6]

GHOSAL S, 1979, J AGR FOOD CHEM, V27, P1347, DOI 10.1021/jf60226a018

[7] Fungal endophytes and their role in plant protection [J].

Gimenez, C. ;

Cabrera, R. ;

Reina, M. ;

Gonzalez-Coloma, A. .

CURRENT ORGANIC CHEMISTRY, 2007, 11 (08) :707-720

[8]

GORSTALLMAN CP, 1980, J CHEM SOC P1, V11, P2474

[9] Antimycobacterial naphthopyrones from Senna obliqua [J].

Graham, JG ;

Zhang, HJ ;

Pendland, SL ;

Santarsiero, BD ;

Mesecar, AD ;

Cabieses, F ;

Farnsworth, NR .

JOURNAL OF NATURAL PRODUCTS, 2004, 67 (02) :225-227

[10] Natural products from plant-associated microorganisms: Distribution, structural diversity, bioactivity, and implications of their occurrence [J].

Gunatilaka, AAL .

JOURNAL OF NATURAL PRODUCTS, 2006, 69 (03) :509-526

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