How I treat CNS lymphomas

被引：151

作者：

Rubenstein, James L. ^{[1
]}

Gupta, Neel K. ^{[1
]}

Mannis, Gabriel N. ^{[1
]}

LaMarre, Amanda K. ^{[2
]}

Treseler, Patrick ^{[3
]}

机构：

[1] Univ Calif San Francisco, Helen Diller Comprehens Canc Ctr, Div Hematol Oncol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Radiat Oncol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA

来源：

BLOOD | 2013年 / 122卷 / 14期

基金：

美国国家卫生研究院;

关键词：

CENTRAL-NERVOUS-SYSTEM; HIGH-DOSE METHOTREXATE; NON-HODGKINS-LYMPHOMA; STEM-CELL TRANSPLANTATION; RECURRENT PRIMARY CNS; COMPARATIVE GENOMIC HYBRIDIZATION; PRIMARY CEREBRAL LYMPHOMA; WHOLE-BRAIN RADIOTHERAPY; QUALITY-OF-LIFE; INTRAOCULAR LYMPHOMA;

D O I：

10.1182/blood-2013-06-453084

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The pathogenesis of primary and secondary central nervous system (CNS) lymphoma poses a unique set of diagnostic, prognostic, and therapeutic challenges. During the past 10 years, there has been significant progress in the elucidation of the molecular properties of CNS lymphomas and their microenvironment, as well as evolution in the development of novel treatment strategies. Although a CNS lymphoma diagnosis was once assumed to be uniformly associated with a dismal prognosis, it is now reasonable to anticipate long-term survival, and possibly a cure, for a significant fraction of CNS lymphoma patients. The pathogenesis of CNS lymphomas affects multiple compartments within the neuroaxis, and proper treatment of the CNS lymphoma patient requires a multidisciplinary team with expertise not only in hematology/oncology but also in neurology, neuroradiology, neurosurgery, clinical neuropsychology, ophthalmology, pathology, and radiation oncology. Given the evolving principles of management and the evidence for improvements in survival, our goal is to provide an overview of current knowledge regarding the pathogenesis of CNS lymphomas and to highlight promising strategies that we believe to be most effective in establishing diagnosis, staging, and therapeutic management.

引用

页码：2318 / 2330

页数：13