Role of circulating tumor DNA in the management of early-stage lung cancer

被引：30

作者：

Zhao, Heng ^{[1
]}

Chen, Ke-Zhong ^{[1
]}

Hui, Ben-Gang ^{[1
]}

Zhang, Kai ^{[1
]}

Yang, Fan ^{[1
]}

Wang, Jun ^{[1
]}

机构：

[1] Peking Univ, Peoples Hosp, Dept Thorac Surg, 11 Xizhimen South St, Beijing 100035, Peoples R China

来源：

THORACIC CANCER | 2018年 / 9卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Circulating tumor DNA; diagnosis; lung cancer; surveillance; FACTOR RECEPTOR MUTATIONS; LIQUID BIOPSIES; EGFR MUTATION; PLASMA; TISSUE; SERUM; LOCALIZATION; CLEARANCE; DIAGNOSIS; BIOMARKER;

D O I：

10.1111/1759-7714.12622

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lung cancer is one of the most common cancers and the predominant cause of cancer-related death in the world. The low accuracy of early detection techniques and high risk of relapse greatly contribute to poor prognosis. An accurate clinical tool that can assist in diagnosis and surveillance is urgently needed. Circulating tumor DNA (ctDNA) is free DNA shed from tumor cells and isolated from peripheral blood. The genomic profiles of ctDNA have been shown to closely match those of the corresponding tumors. With the development of approaches with high sensitivity and specificity, ctDNA plays a vital role in the management of lung cancer as a result of its reproducible, non-invasive, and easy-to-obtain characteristics. However, most previous studies have focused on advanced lung cancer. Few studies have investigated ctDNA in the early stages of the disease. In this review, we focus on ctDNA obtained from patients in the early stage of lung cancer, provide a summary of the related literature to date, and describe the main approaches to ctDNA and the clinical applications.

引用

页码：509 / 515

页数：7

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