A Tether is a Tether is a Tether: Tethering at Membrane Contact Sites

被引:273
作者
Eisenberg-Bord, Michel [1 ]
Shai, Nadav [1 ]
Schuldiner, Maya [1 ]
Bohnert, Maria [1 ]
机构
[1] Weizmann Inst Sci, Dept Mol Genet, IL-7610001 Rehovot, Israel
基金
欧洲研究理事会;
关键词
OXYSTEROL-BINDING PROTEIN; CELL-ADHESION MOLECULES; ENDOPLASMIC-RETICULUM; PLASMA-MEMBRANE; SACCHAROMYCES-CEREVISIAE; ER-MITOCHONDRIA; OUTER-MEMBRANE; LIPID-TRANSFER; EXTENDED SYNAPTOTAGMINS; CHOLESTEROL TRANSPORT;
D O I
10.1016/j.devcel.2016.10.022
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Membrane contact sites enable interorganelle communication by positioning organelles in close proximity using molecular "tethers." With a growing understanding of the importance of contact sites, the hunt for new contact sites and their tethers is in full swing. Determining just what is a tether has proven challenging. Here, we aim to delineate guidelines that define the prerequisites for categorizing a protein as a tether. Setting this gold standard now, while groups from different disciplines are beginning to explore membrane contact sites, will enable efficient cooperation in the growing field and help to realize a great collaborative opportunity to boost its development.
引用
收藏
页码:395 / 409
页数:15
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