A new structure of a serotonin salt: comparison and conformational analysis of all known serotonin complexes

被引：9
作者：
Rychkov, Denis [1 ,2 ]
Boldyreva, Elena V. [1 ,2 ]
Tumanov, Nikolay A. [1 ,2 ,3 ]
机构：
[1] Novosibirsk State Univ, REC 008, Novosibirsk 630090, Russia
[2] Russian Acad Sci, Inst Solid State Chem, Siberian Branch, Novosibirsk 630128, Russia
[3] Catholic Univ Louvain, Inst Condensed Matter & Nanosci, B-1348 Louvain, Belgium
来源：
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY | 2013年 / 69卷
关键词：
crystal structure; serotonin adipate; conformation; hydrogen bonding; stacking interactions; Hirshfeld surfaces; MOLECULAR-STRUCTURE; CRYSTAL; CREATININE;
D O I：
10.1107/S0108270113019823
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Four serotonin salt structures (serotonin adipate, C10H13-N2O +C6H9O4-, is a previously unknown structure) were analysed to understand the influence of the anion on serotonin conformation. Hydrogen bonding alone favours a flat conformation, whereas additional stacking interactions between ions may possibly account for the nonplanar conformation. Since molecular conformation, stability and biological activity are interrelated, one can consider influencing the chemical and biological properties of serotonin by selecting an appropriate counter-ion for salt formation.
引用
收藏
页码：1055 / +
页数：12
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