Human iPSC application in Alzheimer's disease and Tau-related neurodegenerative diseases

被引：27

作者：

Julia, T. C. W. ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Neurosci, Ronald M Loeb Ctr Alzheimers Dis, New York, NY 10029 USA

来源：

NEUROSCIENCE LETTERS | 2019年 / 699卷

关键词：

Alzheimer's disease (AD); Induced pluripotent stem cells (iPSCs); Disease modeling; Tauophaty; PLURIPOTENT STEM-CELLS; FUNCTIONAL CORTICAL-NEURONS; GAMMA-SECRETASE ACTIVITY; FRONTOTEMPORAL DEMENTIA; APOLIPOPROTEIN E4; AMYLOID-BETA; DIFFERENTIATION; MICROGLIA; MODEL; MUTATION;

D O I：

10.1016/j.neulet.2019.01.043

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by beta-amyloid (A beta) plaques and neurofibrillary tangles with progressive cognitive decline. After years of research with failed clinical trials surrounding A beta and tau using numerous in vitro and in vivo AD transgenic animals, human model is necessary to advance our understanding of AD and drug discovery. Induced pluripotent stem cells (iPSCs) offers a novel approach for the establishment of a human model that reflects human genetics and physiology to investigate mechanisms of AD and other forms of dementia, which potentially could lead to a drug discovery, followed by treatment for the disease. In this review, I discuss the advantages in using iPSC technology with various forms of modeling, the progress that has been made to date in patient-derived AD iPSC model and challenges posed by using this technology. Finally, I suggest the future directions of disease modeling and the potential of iPSC technology in AD and other neurodegenerative research.

引用

页码：31 / 40

页数：10

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