Fabrication of tough poly(ethylene glycol)/collagen double network hydrogels for tissue engineering

被引：26
|
作者：
Chen, Jing-Xiao [1 ]
Yuan, Jing [1 ]
Wu, Ya-Ling [1 ]
Wang, Ping [2 ]
Zhao, Peng [3 ]
Lv, Guo-Zhong [3 ]
Chen, Jing-Hua [1 ]
机构：
[1] Jiangnan Univ, Sch Pharmaceut Sci, Wuxi 214122, Peoples R China
[2] Jiangnan Univ, Minist Educ, Key Lab Sci & Technol Ecotext, Wuxi 214122, Peoples R China
[3] Nantong Univ, Affiliated Hosp 3, Dept Burns & Plast Surg, Wuxi 214041, Peoples R China
来源：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2018年 / 106卷 / 01期
基金：
中国国家自然科学基金;
关键词：
collagen; double network hydrogel; toughness; poly(ethylene glycol); cell proliferation; HYALURONIC-ACID; SOLID DISPERSIONS; CELL; COLLAGEN; CARTILAGE; DESIGN; SCAFFOLDS;
D O I：
10.1002/jbm.a.36222
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In this study, a series of poly(ethylene glycol)/collagen (PEG/Col) double network (DN) hydrogel is fabricated from PEG and Col. Results of the compressive strength test indicate that the strength and toughness of these DN hydrogels are significantly enhanced. The fracture strength of PEG/Col DN hydrogels increases by 9- to 12-fold compared with that of PEG single network (SN) hydrogel, and by 36- to 48-fold compared with that of Col SN hydrogel. Taking advantage of both PEG and Col building blocks, the PEG/Col DN hydrogels possess a strengthened skeleton. Moreover, the water-storage capability and favorable biocompatibility of Col are effectively maintained. Given that the DN hydrogels can provide the appropriate environment for the adhesion, growth, and proliferation of MC3T3-E1 cells, PEG/Col DN hydrogels have potential as a load-bearing tissue repair material. (C) 2017 Wiley Periodicals, Inc.
引用
收藏
页码：192 / 200
页数：9
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