Synthesis and pharmacological evaluation of N-(6-chlorobenzo[d]thiazol-2-yl)hydrazine carboxamide derivatives of benzothiazole

被引：15

作者：

Gilani, Sadaf J. ^{[1
,2
]}

Khan, Suroor A. ^{[2
]}

机构：

[1] KIET Sch Pharm, Dept Pharmaceut Chem, Ghaziabad 201206, Uttar Pradesh, India

[2] Jamia Hamdard, Dept Pharmaceut Chem, Fac Pharm, New Delhi 110062, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2013年 / 22卷 / 07期

关键词：

Triazolo-thiadiazole; 1,3,4-Oxadiazole; Anti-inflammatory; Analgesic; Ulcerogenic; Lipid peroxidation; 1,3,4-OXADIAZOLE DERIVATIVES; INHIBITORS; DESIGN; DRUGS; ASSAY; SERUM;

D O I：

10.1007/s00044-012-0329-y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 6-substituted-1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole (6a-g) and 1,3,4-oxadiazole (7a-g, 8) derivatives of benzothiazole were synthesized in satisfactory yield and pharmacologically evaluated for their anti-inflammatory, analgesic, ulcerogenic, and lipid peroxidation activities by known experimental models. All the synthesized compounds were in good agreement with elemental and spectral data. Some of the synthesized compounds have significant anti-inflammatory and analgesic activities. Ulcerogenic and irritative action on the gastrointestinal mucosa, in comparison with standard are low.

引用

页码：3316 / 3328

页数：13

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