Randomized Study of Postoperative Single Intravesical Instillation With Pirarubicin and Mitomycin C for Low-risk Bladder Cancer

被引：11

作者：

Yamamoto, Shinya ^{[1
]}

Kageyama, Yukio ^{[2
]}

Fujii, Yasuhisa ^{[1
]}

Aizawa, Taku ^{[3
]}

Urakami, Shinji ^{[1
]}

Fukui, Iwao ^{[1
]}

机构：

[1] Japanese Fdn Canc Res, Canc Inst Hosp, Dept Urol, Tokyo, Japan

[2] Saitama Canc Ctr, Dept Urol, Saitama, Japan

[3] Tokyo Med Univ, Dept Urol, Hachioji Med Ctr, Tokyo, Japan

来源：

ANTICANCER RESEARCH | 2020年 / 40卷 / 09期

关键词：

Single intravesical instillation; low-risk bladder cancer; pirarubicin; mitomycin C; TRANSURETHRAL RESECTION; INTERFERON-ALPHA; RECURRENCE; EPIRUBICIN; PROPHYLAXIS; TUMOR; CHEMOTHERAPY; MULTICENTER; PREVENTS; THIOTEPA;

D O I：

10.21873/anticanres.14535

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: To assess the prophylactic efficacy of postoperative single intravesical instillation with pirarubicin (THP) and mitomycin C (MMC) for low-risk non-muscle-invasive bladder cancer (NMBC). Patients and Methods: A total of 103 clinically low-risk NMBC patients were preoperatively randomized into either THP (n=49) or MMC (n=54) groups. The primary endpoint was recurrence-free survival. Results: The median follow-up periods of the THP and MMC groups were 955 and 1008 days, respectively (p=0.76). Twelve patients (24 5%) in the THP group and 7 (13%) in the MMC group had bladder cancer recurrences. The two-year recurrence-free survival of the THP group and the MMC group was 77.8% and 86.4%, respectively (p=020). Neither groups had severe toxicity. Conclusion: In low-risk NMBC, the prophylactic effect against postoperative single intravesical instillation with THP was not superior to that with MMC.

引用

页码：5295 / 5299

页数：5

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