Randomized Study of Postoperative Single Intravesical Instillation With Pirarubicin and Mitomycin C for Low-risk Bladder Cancer

被引：12
作者：
Yamamoto, Shinya [1 ]
Kageyama, Yukio [2 ]
Fujii, Yasuhisa [1 ]
Aizawa, Taku [3 ]
Urakami, Shinji [1 ]
Fukui, Iwao [1 ]
机构：
[1] Japanese Fdn Canc Res, Canc Inst Hosp, Dept Urol, Tokyo, Japan
[2] Saitama Canc Ctr, Dept Urol, Saitama, Japan
[3] Tokyo Med Univ, Dept Urol, Hachioji Med Ctr, Tokyo, Japan
来源：
ANTICANCER RESEARCH | 2020年 / 40卷 / 09期
关键词：
Single intravesical instillation; low-risk bladder cancer; pirarubicin; mitomycin C; TRANSURETHRAL RESECTION; INTERFERON-ALPHA; RECURRENCE; EPIRUBICIN; PROPHYLAXIS; TUMOR; CHEMOTHERAPY; MULTICENTER; PREVENTS; THIOTEPA;
D O I：
10.21873/anticanres.14535
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: To assess the prophylactic efficacy of postoperative single intravesical instillation with pirarubicin (THP) and mitomycin C (MMC) for low-risk non-muscle-invasive bladder cancer (NMBC). Patients and Methods: A total of 103 clinically low-risk NMBC patients were preoperatively randomized into either THP (n=49) or MMC (n=54) groups. The primary endpoint was recurrence-free survival. Results: The median follow-up periods of the THP and MMC groups were 955 and 1008 days, respectively (p=0.76). Twelve patients (24 5%) in the THP group and 7 (13%) in the MMC group had bladder cancer recurrences. The two-year recurrence-free survival of the THP group and the MMC group was 77.8% and 86.4%, respectively (p=020). Neither groups had severe toxicity. Conclusion: In low-risk NMBC, the prophylactic effect against postoperative single intravesical instillation with THP was not superior to that with MMC.
引用
收藏
页码：5295 / 5299
页数：5
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