Prevalence of glucose-6-phosphate dehydrogenase deficiency in Cameroonian blood donors

被引：10

作者：

Lauden, Stephanie M. ^{[1
]}

Chongwain, Stella ^{[2
]}

Achidi, Anzeh ^{[2
]}

Helm, Ethan ^{[2
]}

Cusick, Sarah E. ^{[3
]}

Krug, Amelia ^{[3
]}

Slusher, Tina M. ^{[3
]}

Lund, Troy C. ^{[3
,4
]}

机构：

[1] Ohio State Univ, Nationwide Childrens Hosp, Columbus, OH 43210 USA

[2] Mbingo Baptist Hosp, Mbingo, Cameroon

[3] Univ Minnesota, Dept Pediat, Div Global Pediat, Minneapolis, MN 55455 USA

[4] Univ Minnesota, Pediat Blood & Marrow Transplant Program, Stem Cell Inst, Global Pediat, MMC 366,420 Delaware St SE, Minneapolis, MN 55455 USA

来源：

BMC RESEARCH NOTES | 2019年 / 12卷 / 1期

关键词：

Africa; Blood donor; G6PD deficiency;

D O I：

10.1186/s13104-019-4226-z

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

ObjectiveDeficiency in G6PD is the most common enzymopathy worldwide. It is frequently found in individuals of African descent in whom it can lead to hemolytic crises triggered by the use of certain antimalarial medications and infection. The prevalence of G6PD deficiency and its contribution to morbidity in West Africa is under-studied. To understand the prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in West African blood donors.ResultsWe evaluated the G6PD status and infectious disease screening tests of 1001 adult male Cameroonian blood donors (mean age 31.7 +/- 9.8years). The prevalence of G6PD deficiency was 7.9%. There was no difference in levels of hemoglobin or ABO subtype between those who were G6PD-normal compared to those that were deficient. Interestingly, G6PD-normal vs. deficient blood donors were less likely to have screened positive for hepatitis C virus (p=0.02) and rapid plasma reagin (indicative of syphilis, p=0.03). There was no significant difference in hepatitis B sAg, HIV-1, or HIV-2 reactivity between those with vs. without G6PD sufficiency. These data suggest that G6PD deficiency is common among West African male blood donors and may be associated with specific infectious disease exposure.

引用

页数：5

共 26 条

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