Lithium prevents scopolamine-induced memory impairment in zebrafish

被引：40

作者：

Zanandrea, Rodrigo ^{[1
]}

Abreu, Murilo S. ^{[1
,2
]}

Piato, Angelo ^{[3
]}

Barcellos, Leonardo J. G. ^{[1
,2
,4
]}

Giacomini, Ana C. V. V. ^{[1
,2
,5
]}

机构：

[1] Univ Passo Fundo, BR 285, BR-99052900 Passo Fundo, RS, Brazil

[2] Univ Fed Santa Maria, Programa Posgrad Farmacol, Av Roraima,1000 Cidade Univ, BR-97105900 Santa Maria, RS, Brazil

[3] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Programa Posgrad Farmacol & Terapeut, Av Sarmento Leite 500-305, BR-90050170 Porto Alegre, RS, Brazil

[4] Univ Passo Fundo, Programa Posgrad Bioexpt, BR 285, BR-99052900 Passo Fundo, RS, Brazil

[5] Univ Passo Fundo, Programa Posgrad Ciencias Ambientais, BR 285, BR-99052900 Passo Fundo, RS, Brazil

来源：

NEUROSCIENCE LETTERS | 2018年 / 664卷

关键词：

Acetylcholinesterase; Anxiety; Memory; Alzheimer's disease; Cognition; ALZHEIMERS-DISEASE; ACETYLCHOLINESTERASE ACTIVITY; MUSCARINIC RECEPTORS; DANIO-RERIO; THERAPEUTICS; CARBONATE; BRAIN; RATS;

D O I：

10.1016/j.neulet.2017.11.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined whether lithium carbonate (Li2CO3, 100 mg/L) is able to prevent memory impairment induced by scopolamine. Moreover, we evaluated the effects of lithium on anxiety-like behavior and acetylcholinesterase activity in adult zebrafish. We demonstrated that lithium prevents the memory impairment induced by scopolamine, decreases exploration and increases the activity of acetylcholinesterase in zebrafish. Collectively, this contributes to a better understanding of the pharmacology of lithium, its interaction with cholinergic neuro-transmission, and its possible application to therapeutic treatments aimed at improving cognition.

引用

页码：34 / 37

页数：4

共 29 条

[1] Amyloid beta 25-35 impairs reconsolidation of object recognition memory in rats and this effect is prevented by lithium carbonate [J].