Rutin and quercetin, bioactive compounds from tartary buckwheat, prevent liver inflammatory injury

被引：143

作者：

Lee, Chia-Chen ^{[1
]}

Shen, Siou-Ru ^{[1
]}

Lai, Ying-Jang ^{[2
]}

Wu, She-Ching ^{[1
]}

机构：

[1] Natl Chiayi Univ, Dept Food Sci, Chiayi 60004, Taiwan

[2] Natl Quemoy Univ, Dept Food Sci, Kinmen, Taiwan

来源：

FOOD & FUNCTION | 2013年 / 4卷 / 05期

关键词：

GLUTATHIONE S-TRANSFERASES; CARBON-TETRACHLORIDE; CHRONIC ETHANOL; ANTIOXIDANT ACTIVITY; ISOLATED HEPATOCYTES; HEPATOTOXICITY; RATS; ACID; SUPPLEMENTATION; METABOLISM;

D O I：

10.1039/c3fo30389f

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tartary buckwheat (Fagopyrum tataricum) is a healthy and nutritionally important food item. In this study, we investigated the hepatoprotective effects of 75% ethanol extracts from tartary buckwheat (EEB) against ethanol-and carbon tetrachloride (CCl4)-induced liver damage. EEB were administered to C57BL/6 mice (ethanol induction) and Sprague-Dawley (SD) rats (CCl4 induction) for 4 and 8 consecutive weeks, respectively. The major active compounds, rutin and quercetin, were also administered to ethanol-and CCl4-induced animals. EEB inhibited increase in serum aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) levels in the ethanol-and CCl4-induced animals; similar effects were found after rutin and quercetin administration. Moreover, EEB elevated the antioxidant enzyme activities, including those of catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and superoxide dismutase (SOD), and inhibited the levels of hepatic inflammation in the ethanol-and CCl4-treated animals. This study suggests that EEB exerts hepatoprotection via promoting anti-oxidative and anti-inflammatory properties against oxidative liver damage.

引用

页码：794 / 802

页数：9

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