REMISSION EFFECT OF VITAMIN C ON ISOFLURANE-INDUCED APOPTOSIS AND ITS MECHANISM

被引：1
作者：
Hu, J. [1 ]
Gao, B. F. [1 ]
Li, H. Q. [1 ]
Zhang, Z. Z. [1 ]
Lei, Y. L. [1 ]
Sun, G. Q. [1 ]
Guo, D. M. [2 ]
机构：
[1] Shandong Jiaotong Hosp, Dept Anesthesia, 12 Wuyingshanzhong Rd, Jinan 250031, Shandong, Peoples R China
[2] Shandong Univ, Shool Publ Hlth, Jinan, Shandong, Peoples R China
来源：
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS | 2016年 / 30卷 / 04期
关键词：
vitamin C; cognitive impairment; isoflurane; apoptosis; POSTOPERATIVE COGNITIVE DYSFUNCTION; ALZHEIMERS-DISEASE; ELDERLY-PATIENTS; SURGERY; OXYGEN; IMPACT;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This study aims to discuss the remission effect of vitamin C on isoflurane-induced apoptosis of rats and its possible mechanism of action, to provide a theoretical basis for postoperative cognitive impairment. Reactive oxygen species (ROS) detection, adenosine triphosphate (ATP) test, MTT method and Morris water maze were applied for detection tests. For data statistics, double factor analysis of variance (ANOVA) and post hoc Bonferroni test were adopted. It was found that vitamin C could slow down the isoflurane-induced accumulation of ROS in H4-APP cells; moreover, it could relieve the activation of caspase-3 and increase cell survival rate to inhibit the occurrence of apoptosis, indicating that ROS was the source of cell toxicity. On the other hand, vitamin C could protect the cells with its antioxidant effect. It was proved that vitamin C could remit isoflurane-induced apoptosis and relieve the decline in learning and memory ability of rats.
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收藏
页码：961 / 969
页数：9
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